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Interactions of Several Lipid-Related Gene Polymorphisms and Cigarette Smoking on Blood Pressure Levels

By Rui-Xing Yin, Dong-Feng Wu, Jin-Zhen Wu, Xiao-Li Cao, Lynn Htet Htet Aung, Lin Miao, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang and Meng Li

Abstract

The interactions of single nucleotide polymorphisms (SNPs) and cigarette smoking on blood pressure levels are limited. The present study was undertaken to detect nine lipid-related SNPs and their interactions with cigarette smoking on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaⅡ, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 935 nonsmokers and 845 smokers. The interactions were detected by factorial regression analysis. The frequencies of genotypes (ACAT-1 and LIPG), alleles (ABCA-1), and both genotypes and alleles (LDL-R, LIPC, PPARD and SCARB1) were different between nonsmokers and smokers (P < 0.05-0.001). The levels of pulse pressure (PP, ABCA-1), and systolic, diastolic blood pressure (SBP, DBP) and PP (LIPC) in nonsmokers were different among the genotypes (P < 0.01-0.001). The levels of SBP (ABCA-1, ACAT-1, LIPG and PCSK9), DBP (ACAT-1, LDL-R, LIPC, PCSK9 and PPARD), and PP (LIPC, LIPG, MTHFR and PCSK9) in smokers were different among the genotypes (P < 0.01-0.001). The SNPs of ABCA-1, ACAT-1 and PCSK9; ACAT-1, LDL-R, MTHFR and PCSK9; and ABCA-1, LIPC, PCSK9 and PPARD were shown interactions with cigarette smoking to influence SBP, DBP and PP levels (P < 0.05-0.001); respectively. The differences in blood pressure levels between the nonsmokers and smokers might partly result from different interactions of several SNPs and cigarette smoking

Topics: Research Paper
Publisher: Ivyspring International Publisher
OAI identifier: oai:pubmedcentral.nih.gov:3354626
Provided by: PubMed Central
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    Citations

    1. 5,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension.
    2. (2005). A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. Clin Exp Hypertens.
    3. (2009). A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet.
    4. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension.
    5. (2004). An association between smoking habits and blood pressure in normotensive Japanese men: a 5-year follow-up study. Drug Alcohol Depend.
    6. and blood pressure of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations.
    7. (2003). Association between AvaII exon 13 polymorphism at the LDL receptor gene different and serum lipid levels in normotensives and essential hypertensives in Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi.
    8. Association between smoking and blood pressure: evidence from the health survey for England.
    9. (2004). Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. J Hypertens.
    10. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet.
    11. Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    12. Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    13. Association of the LIPG 584C>T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    14. Association of the PPARgamma2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia. Genet Mol Res.
    15. Blood pressure and hypertension are associated with 7 loci in the Japanese population.
    16. (1986). Blood pressure in smokers and nonsmokers: epidemiologic findings. Am Heart J.
    17. (1996). Cigarette smoking and blood pressure in a worker population: a cross-sectional study. J Cardiovasc Risk.
    18. (2007). Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption. Hypertens Res.
    19. (2007). Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations. J Lipid Res.
    20. Comparison of hypertension and its risk factors between the Guangxi Bai Ku Yao and Han populations.
    21. (1992). Disease Control and Prevention (CDC). Cigarette smoking among adults—United States,
    22. Disparities in hypertension control advice according to smoking status. Prev Med.
    23. (2000). Do we undertreat hypertensive smokers? A comparison between smoking and non-smoking hypertensives. Blood Press Monit.
    24. Dyslipidemia and the risk of incident hypertension in men.
    25. Effects of Nicotine on angiogenesis and restenosis in a rabbit model.
    26. Effects of smoking cessation on changes in blood pressure and incidence of hypertension: a 4-year follow-up study.
    27. for Blood Pressure Genome-Wide Association Studies,
    28. (2009). Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. J Hypertens.
    29. Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    30. Genome-wide association study identifies eight loci associated with blood pressure.
    31. Genome-wide association study of blood pressure and hypertension.
    32. (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet.
    33. Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and confirmation of a major susceptibility locus on chromosome 6q14.1. Hum Hered.
    34. (2009). Genotype of the CYBA promoter -930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: an observational study. Med Clin (Barc).
    35. (2007). genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem.
    36. (2007). GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension. Biochem Biophys Res Commun.
    37. (2009). Hyperlipidaemia and its risk factors in the Guangxi Bai Ku Yao and Han populations. Public Health Nutr.
    38. (1990). Hypertension prevalence and blood pressure levels in 6
    39. Inflammation, abdominal obesity, and smoking as predictors of hypertension.
    40. (2004). Interaction and relationship between angiotensin converting enzyme gene and environmental factors predisposing to essential hypertension in Mongolian population of China. Biomed Environ Sci.
    41. Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort.
    42. (1996). Interaction between fibrillin genotype and blood pressure and the development of aneurysmal disease.
    43. Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    44. Peroxisome proliferator-activated receptor delta +294T>C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    45. Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project.
    46. Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level
    47. Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    48. (2005). PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome. Zhonghua Xin Xue Guan Bing Za Zhi.
    49. Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program.
    50. Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism on blood pressure.
    51. (2009). Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One.
    52. (2008). The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch Med Res.
    53. (2004). The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res.
    54. (2003). The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values. Clin Exp Hypertens.
    55. The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness. Physiol Res.
    56. The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis.
    57. The risk of hypertension in men: direct and indirect effects of chronic smoking.

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