Skip to main content
Article thumbnail
Location of Repository

Total Thiols: Biomedical Importance And Their Alteration In Various Disorders

By Prakash Mungli, Mahesh S Shetty, Prasiddha Tilak and Naureen Anwar

Abstract

Thiols are the organic compounds that contain a sulphydryl group. Among all the antioxidants that are available in the body, thiols constitute the major portion of the total body antioxidants and they play a significant role in defense against reactive oxygen species. Total thiols composed of both intracellular and extracellular thiols either in the free form as oxidized or reduced glutathione, or thiols bound to proteins. Among the thiols that are bound to proteins, albumin makes the major portion of the protein bound thiols, which binds to sufhydryl group at its cysteine-34 portion. Apart from their role in defense against free radicals, thiols share significant role in detoxification, signal transduction, apoptosis and various other functions at molecular level. The thiol status in the body can be assessed easily by determining the serum levels of thiols. Decreased levels of thiols has been noted in various medical disorders including chronic renal failure and other disorders related to kidney, cardiovascular disorders, stroke and other neurological disorders, diabetes mellitus, alcoholic cirrhosis and various other disorders. Therapy using thiols has been under investigation for certain disorder

Topics: Online Journal of Health and Allied Sciences
Publisher: Kakkilaya BS
Year: 2009
OAI identifier: oai:cogprints.org:6664
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/6664/1/20... (external link)
  • http://cogprints.org/6664/ (external link)
  • Suggested articles

    Citations

    1. Age-related influence on thiol, disulphide and protein mixed disulphide levels in human plasma.
    2. (1996). All About Albumin: Biochemistry, Genetics, and Medical Applications.
    3. Comparison of protein carbonyl and total plasma thiol concentrations in patients with complete hydatidiform mole with those in healthy pregnant women. doi
    4. (1998). Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites.
    5. Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy humans.
    6. (1992). Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma.
    7. Hekimoğlu A et al. Neutrophil activation, protein oxidation and ceruloplasmin levels with Henoch- Schönlein purpura.
    8. Is protein disul®de isomerase a redox-dependent molecular chaperone?
    9. Mechanism of S-nitrosothiol formation and degradation mediated by copper ions.
    10. (2008). Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid Redox Signal
    11. On the nature of allosteric transitions: a plausible model.
    12. (1993). Oxidation of low density lipoprotein by thiols: superoxide-dependent and independent mechanisms.
    13. Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson’s disease. doi
    14. (2001). Oxidative stress in Chronic Renal Failure. Nephrol Dial Transplant.
    15. Oxidative stress in primary glomerular diseases: a comparative study.
    16. Oxidative stress in uremia.
    17. Oxidative stress is increased in critically ill patients with acute renal failure.
    18. Plasma protein thiols and total antioxidant power in paediatric nephrotic syndrome.
    19. Protein oxidation status in patients with ankylosing spondylitis.
    20. Protein thiol oxidation and lipid peroxidation in patients with uremia.
    21. (2000). Redox state of glutathione in human plasma. Free Radic Biol Med
    22. Serum Paraoxonase activity and protein thiols in chronic renal failure patients.
    23. Total Thiols: Biomedical Importance And Their Alteration In Various Disorders.
    24. Urinary protein thiols in different grades of proteinuria.
    25. Urine protein thiols in chronic renal failure patients.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.