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The Effect of Ketoconazole on Post-Burn Inflammation, Hypermetabolism and Clinical Outcomes

By Marc G. Jeschke, Felicia N. Williams, Celeste C. Finnerty, Noe A. Rodriguez, Gabriela A. Kulp, Arny Ferrando, William B. Norbury, Oscar E. Suman, Robert Kraft, Ludwik K. Branski, Ahmed M. Al-mousawi and David N. Herndon
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3350497
Provided by: PubMed Central
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    Citations

    1. (2009). Abnormal insulin sensitivity persists up to three years in pediatric patients postburn.
    2. (1993). Acute response of human muscle protein to catabolic hormones.
    3. (2007). American Burn Association consensus conference to define sepsis and infection in burns.
    4. (2005). Antiinflammatory action of glucocorticoids–new mechanisms for old drugs.
    5. (2009). Assessment of tissue cortisol activity.
    6. (1978). Aulick LH
    7. (2007). Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients.
    8. (2006). Body composition changes with time in pediatric burn patients.
    9. (2007). Burn size determines the inflammatory and hypermetabolic response.
    10. (1992). Cardiovascular disorders. In:
    11. (1974). Catecholamines: mediator of the hypermetabolic response to thermal injury.
    12. (2007). Changes in liver function and size after a severe thermal injury.
    13. (1979). Circadian rhythms of serum aldosterone, cortisol and plasma renin activity in burn injuries.
    14. (2004). Circulating leptin and cortisol after burn injury: loss of diurnal pattern.
    15. (2006). Cytokine expression profile over time in severely burned pediatric patients.
    16. (2000). Determinants of skeletal muscle catabolism after severe burn.
    17. (2006). Diagnosis of adrenal insufficiency in severe sepsis and septic shock.
    18. (1996). Differential diagnosis and management of Cushing’s syndrome.
    19. (1995). Effect of cortisol on energy expenditure and amino acid metabolism in humans.
    20. (2001). Efficacy of a high-carbohydrate diet in catabolic illness.
    21. (2004). Evidence supporting a role of glucocorticoids in short-term bone loss in burned children.
    22. (1981). Gynecomastia with ketoconazole.
    23. (2006). Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children.
    24. (1989). Improved myocardial oxygen utilization following propranolol infusion in adolescents with postburn hypermetabolism.
    25. (1980). In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.
    26. (1999). Inactivity amplifies the catabolic response of skeletal muscle to cortisol.
    27. (2004). Increased liver weights in severely burned children: comparison of ultrasound and autopsy measurements.
    28. (1982). Ketoconazole blocks adrenal steroid synthesis.
    29. (1983). Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.
    30. (1985). Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11 beta-hydroxylase.
    31. (2000). Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
    32. (2002). Loss of body cell mass in Cushing’s syndrome: effect of treatment.
    33. (1995). Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.
    34. (2005). Metabolic and hormonal changes of severely burned children receiving longterm oxandrolone treatment.
    35. (1995). Muscle protein metabolism during sepsis. Biochem Soc Trans 23: 1019–1025. Ketoconazole Post-Burn PLoS
    36. (1996). P450-dependent enzymes as targets for prostate cancer therapy.
    37. (2008). Pathophysiologic response to severe burn injury.
    38. (1988). Physiological hypercortisolemia increases proteolysis, glutamine, and alanine production.
    39. (2005). Principles and Practice of Kinetic Analysis.
    40. (1987). Response of pituitaryadrenal axis to corticotrophin releasing hormone in patients with Cushing’s disease before and after ketoconazole treatment.
    41. (2007). Restoration of hormonal action and muscle protein.
    42. (2001). Reversal of catabolism by beta-blockade after severe burns.
    43. (2003). Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans.
    44. (2004). Support of the metabolic response to burn injury.
    45. (2000). The Acute Respiratory Distress Syndrome Network
    46. (2007). The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn.
    47. (2006). The influence of age and gender on resting energy expenditure in severely burned children.
    48. (2006). The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly.
    49. (2008). Urinary cortisol and catecholamine excretion after burn injury in children.

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