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Overstimulation of NMDA Receptors Impairs Early Brain Development in vivo

By Tomomi Aida, Yoshimasa Ito, Yuko K. Takahashi and Kohichi Tanaka
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central
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    3. (2007). Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.
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    5. (2000). Cellular and molecular neuropathology of the parahippocampal region in schizophrenia.
    6. (2008). Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.
    7. (2000). Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus.
    8. (1992). Developmental changes in distribution of NMDA receptor channel subunit mRNAs.
    9. (1992). Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat.
    10. (1997). Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.
    11. (2002). Excitatory actions of gaba during development: the nature of the nurture.
    12. (2006). Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia.
    13. (2001). Genetic animal models: Focus on schizophrenia.
    14. (1991). Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing.
    15. (2008). Holmes A
    16. (2006). Indispensability of the glutamate transporters GLAST and GLT1 to brain development.
    17. (1994). Kainate receptor gene expression in the developing rat brain.
    18. (1997). Ketamineinduced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics.
    19. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
    20. (2006). Modeling madness in mice: One piece at a time.
    21. (1998). Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.
    22. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction.
    23. (2004). NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex.
    24. (2007). NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons.
    25. (1997). NMDA receptor-dependent refinement of somatotopic maps.
    26. (2001). Perinatal brain injury: from pathogenesis to neuroprotection.
    27. (2010). Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes.
    28. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
    29. (1991). Recent advances in the phencyclidine model of schizophrenia.
    30. (2007). Reichenberg A
    31. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
    32. (2001). The emerging role of glutamate in the pathophysiology and treatment of schizophrenia.
    33. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited.
    34. (1999). The neuropathology of schizophrenia. A critical review of the data and their interpretation.
    35. (1994). Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice.
    36. (2003). White matter changes in schizophrenia: evidence for myelin-related dysfunction.

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