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Celiac disease in type 1 diabetes mellitus

By Maria Erminia Camarca, Enza Mozzillo, Rosa Nugnes, Eugenio Zito, Mariateresa Falco, Valentina Fattorusso, Sara Mobilia, Pietro Buono, Giuliana Valerio, Riccardo Troncone and Adriana Franzese


Celiac Disease (CD) occurs in patients with Type 1 Diabetes (T1D) ranging the prevalence of 4.4-11.1% versus 0.5% of the general population. The mechanism of association of these two diseases involves a shared genetic background: HLA genotype DR3-DQ2 and DR4-DQ8 are strongly associated with T1D, DR3-DQ2 with CD. The classical severe presentation of CD rarely occurs in T1D patients, but more often patients have few/mild symptoms of CD or are completely asymptomatic (silent CD). In fact diagnosis of CD is regularly performed by means of the screening in T1D patients. The effects of gluten-free diet (GFD) on the growth and T1D metabolic control in CD/T1D patient are controversial. Regarding of the GFD composition, there is a debate on the higher glycaemic index of gluten-free foods respect to gluten-containing foods; furthermore GFD could be poorer of fibers and richer of fat. The adherence to GFD by children with CD-T1D has been reported generally below 50%, lower respect to the 73% of CD patients, a lower compliance being more frequent among asymptomatic patients. The more severe problems of GFD adherence usually occur during adolescence when in GFD non compliant subjects the lowest quality of life is reported. A psychological and educational support should be provided for these patients

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Publisher: BioMed Central
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    1. (2002). A: Severe clinical onset of diabetes and increased prevalence of other autoimmune diseases in children with coeliac disease diagnosed before diabetes mellitus. Diabetologia
    2. and small bowel immunohistochemical features of children with positive serum
    3. (2001). Coeliac disease and Type 1 diabetes mellitus - the case for screening. Diabet Med
    4. (2005). Coeliac disease in children with type 1 diabetes mellitus: the effect of the gluten free diet. Diabet Med
    5. (2005). Coeliac disease, autoimmune diseases and gluten exposure.
    6. (2006). de Melo FM: Serum prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus.
    7. (2004). Diabetes study group of the Italian Society of Pediatric Endocrinology and Diabetology. Younger age at onset and sex predict celiac disease in children and adolescents with type 1 diabetes: an Italian multicenter study. Diabetes Care
    8. (1999). Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease.
    9. (2003). Eisenbarth GS: Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. Rev Endocr Metab Disord
    10. (2006). et al: Clinical review: type 1 diabetes-associated autoimmunity: natural history, genetic associations and screening.
    11. (1999). GS: One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease associated transglutaminase autoantibodies.
    12. (2010). Katic V: Celiac disease prevalence in children and adolescents with type 1 diabetes from Serbia. Pediatr Int
    13. (2000). Not T: Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease.
    14. (2001). Potential and latent coeliac disease.
    15. (2011). Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India.
    16. (2007). Prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus in a clinic based population. Postgrad Med J
    17. (2011). Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus.
    18. (2009). Screening for associated autoimmunity in children and adolescents with type 1 diabetes mellitus (T1DM). Horm Res
    19. (2004). Screening of celiac disease in north Italian children with type 1 diabetes: limited usefulness of HLA-DQ typing. Acta Paediatr
    20. (2008). Skane Study Group: Annual screening detects celiac disease in children with type 1 diabetes. Pediatr Diabetes
    21. (2008). Todd JA: Shared and distinct genetic variant in Type 1 diabetes and celiac disease.
    22. (1995). Ventura A: Coeliac disease and insulin-dependent diabetes mellitus: a causal association? Acta Paediatr
    23. (2004). Working Group for Pediatric Diabetology: Anthropometry, metabolic control, and thyroid autoimmunity in type 1 diabetes with celiac disease: A multicenter survey.

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