Skip to main content
Article thumbnail
Location of Repository

Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: A Preliminary Study

By Didin E Indahyani, AL Supartinah Santoso, Totok Utoro, Marsetyawan HNE Soesatyo and Wihaskoro Sosroseno

Abstract

Dietary fish oil has been shown to inhibit bone resorption and, therefore, the aim of the present study was to test the hypothesis that fish oil alters lipopolysaccharide (LPS)-induced hydroxyapatite loss in rat alveolar bone. Rats were divided into four groups. The animals injected with saline or Escherichia coli-derived LPS into the maxillary alveolar mucosa on the buccoapical site of the molar region daily for 8 days were served as a negative or positive control, respectively. Other groups of animals were injected with LPS and orally treated with fish oil at the same day with or after LPS injection. The results of the present study showed that the hydroxyapatite contents of alveolar bone in rats treated with fish oil at the same day with or before LPS injection were significantly higher than those in rats injected with LPS alone, but still lower than those in untreated animals. Therefore, the present study suggests that oral treatment with fish oil may reduce LPS-induced hydroxyapatite loss in rat alveolar bon

Topics: Online Journal of Health and Allied Sciences
Publisher: Dr. B.S. Kakkilaya
Year: 2009
OAI identifier: oai:cogprints.org:6394
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/6394/1/20... (external link)
  • http://cogprints.org/6394/ (external link)
  • Suggested articles

    Citations

    1. Dietary supplementation of omega-3 fatty acid and circulating levels of interleukin-1β, osteocalcin, and C-reactive protein in rats.
    2. Effect of high-density lipoprotein on lipopolysaccharide-induced alveolar bone resorption in rats.
    3. (2008). Extracellular pH regulates bone cell function.
    4. (1999). Influence of dietary n-3 polyunsaturated fatty acid on experimental tooth movement in rats. Angle Orthod.
    5. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism.
    6. (2001). Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology.
    7. Omega-3 fatty acid effect on alveolar bone loss in rats.
    8. (2002). The effect of fish oil on bone resorption following pulp exposure in rats. Dent Traumatol.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.