(2007). Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release.
(2000). Arguments for interleukin 1 as a target in chronic arthritis.
(2003). ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
(2005). ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP.
(1996). Biologic basis for interleukin-1 in disease.
(1998). Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling.
(2007). Coexistent MEFV and CIAS1 mutations manifesting as familial Mediterranean fever plus deafness.
(2009). Combined polymorphisms in genes encoding the inflammasome components Activating Polymorphism
(2007). Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever.
(2011). Cross-regulation between the IL-1beta/ IL-18 processing inflammasome and other inflammatory cytokines.
(2008). Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
(2007). Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.
(2004). Cryopyrininduced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.
(2006). Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways.
(2008). Cutting edge: inflammasome activation by alum and alum’s adjuvant effect are mediated by NLRP3.
(2009). Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
(2009). Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
(2002). De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
(2007). Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.
(2009). Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease.
(2008). Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
(2008). Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford)