Article thumbnail

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

By Marko Jović, Michelle J. Kean, Zsofia Szentpetery, Gordon Polevoy, Anne-Claude Gingras, Julie A. Brill and Tamas Balla

Abstract

Trafficking of glucocerebrosidase (GBA) enzyme from the endoplasmic reticulum to the lysosome requires lysosomal integral membrane protein type 2 (LIMP-2), which is a receptor for GBA. This study shows that phosphatidylinositol 4-kinase (PI4K) type IIIβ controls the exit of LIMP-2/GBA complex from the Golgi, while PI4KIIα is required for the post-Golgi trafficking of the complex via the late endosomes

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3327330
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.