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ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis

By Kara A. Boltz, Katherine Leehy, Xiangyu Song, Andrew D. Nelson and Dorothy E. Shippen

Abstract

Telomeres protect chromosome ends from DNA damage. CTC1/STN1/TEN1 (CST), a core telomere-capping complex in plant and vertebrates, suppresses an ATR-dependent DNA damage response in Arabidopsis. Protracted ATR inactivation inhibits telomerase, hastening the onset of telomere dysfunction in CST mutants

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3327312
Provided by: PubMed Central
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