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Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion

By Bernadette C Victor, Arulselvi Anbalagan, Mona M Mohamed, Bonnie F Sloane and Dora Cavallo-Medved
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3326557
Provided by: PubMed Central

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  1. (1985). A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.
  2. (2008). are associated with breast cancer basal-like and triple-negative immunophenotype.
  3. (2011). BF: Cathepsin B: a potential prognostic marker for inflammatory breast cancer.
  4. (2005). BF: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.
  5. (2000). BF: Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.
  6. (1992). BF: Human tumour cathepsin B. Comparison with normal liver cathepsin B. Biochem J
  7. (2009). BF: Imaging and quantifying the dynamics of tumor-associated proteolysis. Clin Exp Metastasis
  8. (2000). BF: Imaging proteolysis by living human breast cancer cells. Neoplasia
  9. (2009). BF: Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res
  10. (2011). BF: Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment. Biochim Biophys Acta
  11. (2003). BF: Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. Neoplasia
  12. (1994). BF: Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res
  13. (2008). BF: Visualizing protease activity in living cells: from two dimensions to four dimensions. Curr Protoc Cell Biol
  14. (1995). BM: The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.
  15. (2005). Brugge JS: Modelling glandular epithelial cancers in threedimensional cultures. Nat Rev Cancer
  16. (2005). Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol
  17. (2011). Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma. Cancer Gene Ther
  18. (1999). Chapman HA: A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling.
  19. (2001). CL: Transgenic polyoma middle-T mice model premalignant mammary disease. Cancer Res
  20. (2005). Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Res Treat
  21. (1999). Ethier SP: Molecular cytogenetic analysis of 11 new breast cancer cell lines.
  22. (2001). Expression of the urokinase-type plasminogen activator receptor in human articular chondrocytes: association with caveolin and beta 1-integrin. Histochem Cell Biol
  23. (1986). F: Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.
  24. (2003). Family C1 cysteine proteases: biological diversity or redundancy? Biol Chem
  25. (1998). Finberg RW: Determination of the non-ionic detergent insolubility and phosphoprotein associations of glycosylphosphatidylinositol-anchored proteins expressed on T cells.
  26. (2004). Gilad E: CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
  27. (1991). Graeff H: Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
  28. (2008). Henrique-Silva F: Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion. Biol Chem
  29. (1975). Hursting SD: Inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and Victor
  30. (2009). Inflammatory breast carcinoma as a model of accelerated self-metastatic expansion by intravascular growth.
  31. (2011). International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol
  32. (2001). Invasion activating caveolin-1 mutation in human scirrhous breast cancers. Cancer Res
  33. (2004). JS: RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene
  34. (1991). Katunuma N: Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro.
  35. (2006). KL: Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer. Breast Cancer Res Treat
  36. (2009). Le Guennec JY: Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
  37. (2001). MC: Cell biology of caveolae and caveolin. Adv Drug Deliv Rev
  38. (2010). Merajver SD: Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers. Cancer
  39. (2004). Merajver SD: WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer. Breast Cancer Res
  40. (2009). MP: Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasisassociated gene signature.
  41. (2008). Nabi IR: Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res
  42. (2004). Pestell RG: Caveolin-1 in breast cancer. Cancer Biol Ther
  43. (2002). Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.
  44. (1995). Piana L: Inflammatory carcinomas of the breast: a clinical, pathological, or a clinical and pathological definition?
  45. (2010). Rao JS: Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS One
  46. (2008). Reinheckel T: Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene
  47. (2006). Reinheckel T: Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res
  48. (2009). RJ: Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res
  49. (2010). S: Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist. PLoS One
  50. (1999). SH: A novel human xenograft model of inflammatory breast cancer. Cancer Res
  51. (2003). Sloane BF: Cell-surface cathepsin B: understanding its functional significance. Curr Top Dev Biol
  52. (2006). Sloane BF: Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer
  53. (2010). Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells. Cancer Gene Ther
  54. (1993). Terao T: Effects of membrane-associated cathepsin B on the activation of receptorbound prourokinase and subsequent invasion of reconstituted basement membranes. Biochim Biophys Acta
  55. (1992). Terao T: Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B. Cancer Res
  56. (1994). The annexin II2p11(2) complex is the major protein component of the triton X-100-insoluble low-density fraction prepared from MDCK cells in the presence of Ca2+. Biochim Biophys Acta
  57. (2008). The cancer degradome: proteases and cancer biology.Edited by: Dylan Edwards, Francesco Blasi, Gunilla Hoyer-Hansen, Bonnie Sloane.
  58. (2005). Turk V: Carboxypeptidases cathepsins × and B display distinct protein profile in human cells and tissues. Exp Cell Res
  59. (2008). Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol

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