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Transcranial Magnetic Stimulation with the Maximum Voluntary Muscle Contraction Facilitates Motor Neuron Excitability and Muscle Force

By Tetsuo Touge, Yoshiteru Urai, Kazuyo Ikeda, Kodai Kume and Kazushi Deguchi


Three trials of transcranial magnetic stimulation (TMS) during the maximum voluntary muscle contraction (MVC) were repeated at 15-minute intervals for 1 hour to examine the effects on motor evoked potentials (MEPs) in the digital muscles and pinching muscle force before and after 4 high-intensity TMSs (test 1 condition) or sham TMS (test 2 condition) with MVC. Under the placebo condition, real TMS with MVC was administered only before and 1 hour after the sham TMS with MVC. Magnetic stimulation at the foramen magnum level (FMS) with MVC was performed by the same protocol as that for the test 2 condition. As a result, MEP sizes in the digital muscles significantly increased after TMS with MVC under test conditions compared with the placebo conditions (P < 0.05). Pinching muscle force was significantly larger 45 minutes and 1 hour after TMS with MVC under the test conditions than under the placebo condition (P < 0.05). FMS significantly decreased MEP amplitudes 60 minutes after the sham TMS with MVC (P < 0.005). The present results suggest that intermittently repeated TMS with MVC facilitates motor neuron excitabilities and muscle force. However, further studies are needed to confirm the effects of TMS with MVC and its mechanism

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Publisher: Hindawi Publishing Corporation
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    1. (2007). a l l ya n dT .W .S t o n e ,“ N e wa d v a n c e si nt h er e h a b i l i t a t i o n of CNS diseases applying rTMS,”
    2. (1999). Altered responses of human elbow flexors to peripheral-nerve and cortical stimulation during a sustained maximal voluntary contraction,”
    3. (1991). An introduction to the basic principles of magnetic nerve stimulation,”
    4. (2001). Changes in corticomotor representations induced by prolonged peripheral nerve stimulation in humans,”
    5. (1996). Effect of transcranial magnetic stimulation over the cerebellum on the excitability of human motor cortex,”
    6. (2004). Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation,”
    7. (2006). H a r r i s - L o v ea n dL .G .C o h e n ,“ N o n i n v a s i v ec o r t i c a l stimulation in neurorehabilitation: a review,”
    8. (2002). Increase in hand muscle strength of stroke patients after somatosensory stimulation,”
    9. Induction of persistent changes in the organisation of the human motor cortex,”
    10. (2000). Induction of plasticity in the human motor cortex by paired associative stimulation,”
    11. (2005). l i v e r i ,G .K o c h ,S .T o r r i e r o ,a n dC .C a l t a g i r o n e ,“ I n -creasedfacilitationoftheprimarymotorcortexfollowing1Hz repetitive transcranial magnetic stimulation of the contralateral cerebellum in normal humans,”
    12. (1994). Magnetic stimulation of corticospinal pathways at the foramen magnum level in humans,”
    13. (1999). Magnetic Stimulation of the Human Nervous System,
    14. (2002). Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation,”
    15. (2001). Mechanisms of motor-evoked potential facilitation following prolonged dual peripheral and central stimulation in humans,”
    16. (1994). Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application.
    17. (2001). o u g e ,W .G e r s c h l a g e r ,P .B r o w n ,a n dJ .C .R o t h w e l l ,“ A r e the after-effects of low-frequency rTMS on motor cortex excitability duetochanges in theefficacy ofcortical synapses?”
    18. (2005). r b a c h ,A .B e r t h ,a n dF .A w i s z u s ,“ E ffect of transcranial magnetic stimulation on voluntary activation in patients with quadriceps weakness,”
    19. (1997). R.Chen,J.Classen,C.Gerloffetal.,“Depressionofmotorcortex excitability by low-frequency transcranial magnetic stimulation,”
    20. (1994). Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex,”
    21. (2002). rTMS over the cerebellum can increase corticospinal excitability through a spinal mechanism involving activation of peripheral nerve fibres,”
    22. (2004). S.RossiandP.M.Rossini,“TMSincognitiveplasticityandthe potential for rehabilitation,” Trends in Cognitive Sciences,
    23. (2002). Stimulus strength related effect of transcranial magnetic stimulation on maximal voluntary contraction force of human quadriceps femoris muscle,”
    24. (2006). Stroke recovery can be enhanced by using repetitive transcranial magnetic stimulation (rTMS),”
    25. (2000). T a y l o r ,G .M .A l l e n ,J .E .B u t l e r ,a n dS .C .G a n d e v i a ,“ S u -praspinal fatigue during intermittent maximal voluntary contractions of the human elbow flexors,”
    26. (1949). The Organization of Behavior. A Neuropsychological Theory,
    27. (1993). ujirai,M.D .Caramia,J .C.R oth welletal.,“ Corticocortical inhibition in human motor cortex,”
    28. (2007). Use of transcranial magnetic stimulation of the brain in stroke rehabilitation,”

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