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Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells

By Ildiko Györy, Sören Boller, Robert Nechanitzky, Elizabeth Mandel, Sebastian Pott, Edison Liu and Rudolf Grosschedl

Abstract

The transcription factor Ebf1 regulates early B lymphopoiesis by acting in a network with E2A and Pax5. However, the function of Ebf1 at later stages of differentiation in unclear. In this study, Grosschedl and colleagues investigate the role of Ebf1 in B lymphopoiesis by using conditional gene inactivation. The authors show that Ebf1 is required for proliferation and survival of pro-B and mature B cells. In addition, the proliferation defect of Ebf1fl/fl pro-B cells can be overcome by transformation with v-Abl, and the survival defect can be rescued by the expression of the Ebf1 targets c-Myb or Bcl-xL. In mature B cells, Ebf1 deficiency interferes with normal BCR/Akt signaling and the generation of germinal center B cells. Thus, these results delineate novel targets and pathways controlled by Ebf1 at different stages of lymphomagenesis

Topics: Research Paper
Publisher: Cold Spring Harbor Laboratory Press
OAI identifier: oai:pubmedcentral.nih.gov:3323878
Provided by: PubMed Central
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