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Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy

By Gaurav Mrinal Sharma

Abstract

Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cance

Topics: Online Journal of Health and Allied Sciences
Publisher: Dr. B.S. Kakkilaya
Year: 2008
OAI identifier: oai:cogprints.org:6202

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