Article thumbnail

Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex

By Patrizia Turriziani, Daniela Smirni, Giuseppe Zappalà, Giuseppa R. Mangano, Massimiliano Oliveri and Lisa Cipolotti


A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right DLPFC at retrieval by means of repetitive transcranial magnetic stimulation (rTMS) modulate recognition memory performance in 100 healthy controls (HCs) and in eight patients with Mild Cognitive Impairment (MCI). Recognition memory tasks of faces, buildings, and words were used in different experiments. rTMS-inhibition of the right DLPFC enhanced recognition memory in both HCs and MCIs. rTMS-excitation of the same region in HCs deteriorated memory performance. Inhibition of the right DLPFC could modulate the excitability of a network of brain regions, in the ipsilateral as well as in the contralateral hemisphere, enhancing function in HCs or restoring an adaptive equilibrium in MCI

Topics: Neuroscience
Publisher: Frontiers Media S.A.
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2004). A n d e r s o n ,M .C . ,O c h s n e r
  2. (2004). A r o n ,A .R . ,R o b b i n s ,T .W . ,a n d
  3. (2011). accepted: 10
  4. (2004). Age-related functional changes of prefrontal cortex in long-term memory: a repetitive transcranial magnetic stimulation study.
  5. (2002). Aging gracefully: compensatory brain activity in high-performing older adults.
  6. (2001). An examination of the effects of stimulus type, encoding task, and functional connectivity on the role of right prefrontal cortex in recognition memory.
  7. (2005). B h a t i a ,K .P . ,a n dR o t h w e l l
  8. B i r d ,C .M . ,K h a n ,S .S . ,L o s s e f f ,N . , Howard, R.S.,andLeff, A.P.(2008). The role of the thalamus in amnesia: a tractography, high-resolution MRI and neuropsychological study.
  9. (2004). B r a u n ,A .
  10. (1995). B u r a n i ,C . ,a n dM a r c o n i ,L .
  11. (2011). Brain stimulation improves associative memory in an individual with amnestic mild cognitive impairment. Neurocase Sep. 1. [Epub ahead of print] Delis,
  12. (2006). Changes in hippocampal connectivity in the early stages of Alzheimer’s disease: evidence from resting state fMRI.
  13. D e r m o t t ,K .B . ,B u c k n e r
  14. (2012). Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex.
  15. (2009). Event-related fMRI studies of episodic encoding and retrieval: meta-analyses using activation likelihood estimation.
  16. (2002). F a d d a ,L . ,G r a c e f f a ,A . ,M a u r i
  17. (2001). Frontal lobes and human memory. Insights from functional neuroimaging.
  18. (1991). Frontal-lobe contribution to recency judgements.
  19. (2012). Frontiers in Human Neuroscience
  20. (2010). Functional alterations in memory networks in early Frontiers in Human Neuroscience
  21. (1982). H u g h e s ,C .P . ,B e r g ,L . ,D a n z i g e r
  22. (2003). Hemispheric asymmetries of memory: the HERA model revisited.
  23. (2002). Hemispheric asymmetry reduction in older adults: the HAROLD model.
  24. (1999). I v n i k ,R .J . ,T a n g a l o s
  25. (2003). K e i g h t l e y ,M .L . ,B u r i a n
  26. M a c h u l d a ,M .M . ,P e t e r s e n ,R
  27. (2010). M a i o l i ,C . ,a n dM i n i u s s i ,C .
  28. (2004). Memory systems of the brain: a brief history and current perspective.
  29. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician.J.
  30. (2011). Modulation of motor cortex neuronal networks by rTMS: comparison of local and remote effects of six different protocols of stimulation.
  31. (2005). Parietal lobe contributions to episodic memory retrieval.
  32. (2010). Persistent schema-dependent hippocampalneocortical connectivity during memory encoding and postencoding rest in humans.
  33. (2003). Prefrontal andmedialtemporallobe interactions in long-term memory.
  34. (2000). Prefrontal-temporal circuitry for episodic encoding and subsequent memory.
  35. (2002). R o s e n ,A .C . ,P r u l l ,M .W . ,O ’ H a r a ,R . , R a c e ,E .A . ,D e s m o n d
  36. (2001). R o s s i ,S . ,C a p p a ,S .F . ,B a b i l o n i
  37. (1994). R o s s i n i ,P .M . ,B a r k e r ,A .T . ,B e r a r d e l l i
  38. (1984). Recognition Memory Test.W i n d s o r ,B e r k s : NFER-Nelson.
  39. (2008). Recognitionmemory andprefrontal cortex: dissociating recollection and familiarity processes using rTMS.
  40. (2006). Recollection and familiarity in dense hippocampal amnesia: a case study.
  41. (2006). Repetitive transcranial magnetic stimulation effects on brain function and cognition among elders with memory dysfunction. A randomized sham-controlled study.
  42. (2009). S h i ,Y . ,Y u a n ,Y . ,Z a n g
  43. S p e r l i n g ,R .A . ,D i c k e r s o n
  44. (2010). Standardizzazione di tre nuovi test di memoria di riconoscimento verbale e non verbale: uno studio preliminare.
  45. (2011). Successful physiological aging and episodic memory: a brain stimulation study.
  46. (1994). T u l v i n g ,E . ,K a p u r ,S . ,C r a i k
  47. (2007). Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS.
  48. (2001). The cognitive neuroscience of remembering.
  49. (1996). The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The group of the Standardization of the Mental Deterioration Battery.
  50. (2003). The role of prefrontal cortex in verbal episodic memory: rTMS evidence.
  51. (2010). The role of the prefrontal cortex in familiarity and recollection processes during verbal and non-verbal recognition memory: an rTMS study.
  52. (1999). Top-down signal from prefrontal cortex in executive control of memory retrieval.
  53. (2008). V i l b e r g ,K . ,a n dR u g g ,M .D .
  54. (1998). W a g n e r ,A .D . ,P o l d r a c k

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.