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The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies

By Robert E Sinden, Richard Carter, Chris Drakeley and Didier Leroy


A meeting to discuss the latest developments in the biology of sexual development of Plasmodium and transmission-control was held April 5-6, 2011, in Bethesda, MD. The meeting was sponsored by the Bill & Melinda Gates Foundation and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH/NIAID) in response to the challenge issued at the Malaria Forum in October 2007 that the malaria community should re-engage with the objective of global eradication. The consequent rebalancing of research priorities has brought to the forefront of the research agenda the essential need to reduce parasite transmission. A key component of any transmission reduction strategy must be methods to attack the parasite as it passes from man to the mosquito (and vice versa). Such methods must be rationally based on a secure understanding of transmission from the molecular-, cellular-, population- to the evolutionary-levels. The meeting represented a first attempt to draw together scientists with expertise in these multiple layers of understanding to discuss the scientific foundations and resources that will be required to provide secure progress toward the design and successful implementation of effective interventions

Topics: Meeting Report
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2011). A research agenda to underpin malaria eradication. PLoS Med
  2. (2011). A: Reverse genetics in Chlamydomona: a platform for isolating insertional mutants. Plant Methods
  3. (2008). A: Sex ratio adjustment and kin discrimination in malaria parasites. Nature
  4. (2009). Alano P: Egress of Plasmodium berghe gametes from their host erythrocyte is mediated by MDV-1/PEG3 protein. Cell Microbiol
  5. (2005). Alano P: Genome-wide identification of genes upregulated at the onset of gametocytogenesis in Plasmodium falciparu. Mol Biochem Parasitol
  6. (2008). Ambedkar RD: A very large C-loop in EGF domain IV is characteristic of the P28 family of ookinete surface proteins. J Mol Modelling
  7. (1997). Antimalarial drugs and the mosquito transmission of Plasmodium.
  8. (2010). Basanez M-G: Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions.
  9. (2008). Basanez M-G: Progression of Plasmodium berghe through Anopheles stephens is density-dependent. PLoS Pathog
  10. (2008). Billker O: The conserved plant sterility gene HAP functions after attachment of fusogenic membranes in Chlamydomona and Plasmodiu gametes. Genes Dev
  11. (2010). Billker O: The systematic functional analysis of Plasmodiu protein kinases identifies essential regulators of mosquito transmission. Cell Host Microbe
  12. (2011). Bousema T: A clusterrandomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malar J
  13. (1990). Commitment of the malaria parasite Plasmodium falciparu to sexual and asexual development. Parasitology
  14. (1971). Contacos PG: The primate malarias. U.S.Department of Health, Education and Welfare,
  15. (2009). Enhanced antibody responses to Plasmodium falciparu Pfs28 induced in mice by conjugation to ExoProtein A of Pseudomonas aeruginos with an improved procedure. Microbes Infect
  16. (2011). Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametoytes in relation to malaria control and elimination. Clin Micro Reviews
  17. (1996). Fleck SL: Regulation of infectivity of Plasmodiu to the mosquito vector. Adv Parasitol
  18. (1993). Frequency of crossfertilization in the human malaria parasite Plasmodium falciparu. Parasitology
  19. (1982). Gametocytogenesis of Plasmodium falciparum in vitro ultrastructural observations on the lethal action of chloroquine. Ann Trop Med Parasitol
  20. (1999). Genetic structure and dynamics of Plasmodium falciparu infections in the Kilombero region of Tanzania. Trans R Soc Trop Med Hyg
  21. (1992). Giudice G: Mycobacterial heatshock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming.
  22. (1985). Hartley RH: Identification of the meiotic division of malarial parasites.
  23. (2011). HM: Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite’s life cycle. Antimicrob Agents Chemother
  24. (1997). Hogh B: The Matola malaria project: A temporal and spatial study of malaria transmission and disease in a suburban area of Maputo, Mozambique. AmJTrop Med Hyg
  25. (1998). HR: Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito. Nature
  26. (2009). KC: The proteasome inhibitor epoxomicin has potent Plasmodium falciparu gametocytocidal activity. Antimicrob Agents Chemother
  27. (2007). KP: Susceptibility of Anopheles gambia and Anopheles stephens to tropical isolates of Plasmodium falciparu.
  28. (2010). Krudsood S: Long term primaquine administration to reducePlasmodium falciparu gametocyte transmission in hypoendemic areas. Southeast Asian Top Med Public Health
  29. (2010). Measures of efficacy of anti-malarial interventions against malaria transmission,
  30. (1952). Mercier EC: Factors in malaria transmission by Anopheles albimanu in Jamaca. Part 1. Ann Trop Med Parasitol
  31. (1999). Motard A: Periodic infectivity of Plasmodiu gametocytes to the vector. A review. Parasite
  32. (2008). N: Critical role of a K + channel in Plasmodium berghe transmission revealed by targeted gene disruption. PNAS
  33. (1977). Plasmodium falciparu gametocytes: the effect of chloroquine on their development. Trans R Soc Trop Med Hyg
  34. (2009). Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development.
  35. (2004). Preparation, crystallization and preliminary X-ray analysis of a complex between the Plasmodium viva Sinden et al.
  36. (2000). Ranford-Cartwright LC: Commitment to sexual differentiation in the human malaria parasite, Plasmodium falciparu. Parasitology
  37. (2008). Ranford-Cartwright LC: The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparu. Mol Microbiol
  38. (2010). Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine.
  39. (2006). RW: Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparu.
  40. (2007). RW: Submicroscopic Plasmodium falciparu gametocyte densities frequently result in mosquito infection. AmJTrop Med Hyg
  41. (1994). Sinden RE: In situ detection of Pbs21 mRNA during sexual development of Plasmodium berghe. Mol Biochem Parasitol
  42. (1979). Smalley ME: Gametocytogenesis of Plasmodium falciparum in vitr: the cell cycle. Parasitology
  43. (2000). Spatial targeting of interventions against malaria. Bull World Health Organ
  44. (2012). Spatial targeting of malaria for control and elimination: The importance of malaria hotspots. PLoS Med
  45. (2005). Structural models for the protein family characterised by gamete surface protein
  46. (1996). Survival and dispersal of Anopheles gambia complex mosquitoes in a West African Sudan savannah village. Med Vet Entomol
  47. (1938). The action of Atebrin upon gametocytes of Plasmodium falciparu. Riv Malariol
  48. (1987). The complete development in vitr of the vertebrate phase of the mammalian malaria parasite Plasmodium berghe. Trans R Soc Trop Med Hyg
  49. (2011). Tsuboi T: N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complementdependent malaria transmission-blocking activity. Clin Vaccine Immunol
  50. (1994). Walliker D: Random mating in a natural population of the malaria parasite Plasmodium falciparu. Parasitology
  51. (2006). Waters AP: Regulation of sexual development of Plasmodiu by translational repression. Science
  52. (2005). Winzeler EA: The Plasmodium falciparu sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol
  53. (2011). Yusibov V: A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparu. Clin Vaccine Immunol

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