Skip to main content
Article thumbnail
Location of Repository

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

By Alison L. Harte, Nancy F. da Silva, Michelle A. Miller, Francesco P. Cappuccio, Ann Kelly, Joseph P. O'Hare, Anthony H. Barnett, Nasser M. Al-Daghri, Omar Al-Attas, Majed Alokail, Shaun Sabico, Gyanendra Tripathi, Srikanth Bellary, Sudhesh Kumar and Philip G. McTernan

Abstract

South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = −0.419, P < 0.01; r = −0.443, P < 0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3303685
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2010). Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin,”
    2. (2011). An evolutionary review of human telomere biology:thethriftytelomerehypothesisandnotesonpotential adaptive paternal effects,”
    3. (2011). Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease,”
    4. (2007). Change in the telomere length distribution with age
    5. (2009). Constitutive telomere length and gastric cancer risk: casecontrol analysis in Chinese Han population,”
    6. (2009). Dyslipidemia in South Asians living in a western community,”
    7. (2008). Enhanced diabetes care to patients of south Asian ethnic origin (the United Kingdom Asian Diabetes Study): a cluster randomised controlled trial,”
    8. (2008). Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice,”
    9. (2010). Ethnic differences in body composition and the associated metabolic profile: a comparative study between
    10. (2004). Evaluation of delivery of enhanced diabetes care to patients of
    11. (2011). Gender differences in animal models of posttraumatic stress disorder,”
    12. (2007). Hyperinsulinemia and aging,”
    13. (2011). Impact of occupational stress on stroke across occupational classes and genders,”
    14. (2010). Insulin signaling and life span,”
    15. (2011). Introduction to telomeres and telomerase,”
    16. (2011). J.Lin,C.H.Kroenke,E.Epeletal.,“Greaterendogenousestrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline,”
    17. (2009). Lenner,andG.Roos,“Theindividualbloodcelltelomereattrition rate is telomere length dependent,”
    18. (2011). Leukocyte telomere length and marital status among middle-aged adults,”
    19. (2005). M i l l e r ,S .M .K e r ry ,Y .D o n g ,G .A .S a g n e l l a ,D .G .C o o k
    20. (2005). Managing cardiovascular risk in minority patients,”
    21. (2010). Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study,”
    22. (2005). Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population-based cross-sectional study,”
    23. (2011). Obesity-related non-communicable diseases: South Asians vs White Caucasians,”
    24. (2010). Premature cardiovascular events and mortality in south Asians with type 2 diabetes in the United Kingdom Asian Diabetes Study effect of ethnicity on risk,”
    25. (1997). Prevalence, detection, and management of cardiovascular riskfactorsindifferentethnicgroupsinSouthLondon,”Heart,
    26. (2009). Psychological and metabolic stress: a recipe for accelerated cellular aging?” Hormones,
    27. (2009). Race/ethnicity and telomere length in the Multi-Ethnic
    28. (2009). Short telomeres and prognosis of hypertension in a Chinese population,”
    29. (2001). Telomere length as an indicatorofbiologicalagingthegendereffectandrelationwith pulse pressure and pulse wave velocity,”
    30. (2010). Telomere length in atherosclerosis and diabetes,”
    31. (2010). Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth,”
    32. Telomere measurement by quantitative PCR,”
    33. (2007). Telomere shortening and metabolic/vascular diseases,”
    34. (2010). Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells,”
    35. (2011). Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins,”
    36. (2010). The 2009 Noble Prize in Medicine and its surprising message: lifestyle is associated with telomerase activity,”
    37. (2000). The role of stress and the hypothalamicpituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes,”
    38. (1997). Trends in the prevalence of type 2 diabetes in Asians versus whites: results from the United States National Health Interview Survey,
    39. (2010). Tuomilehto et al., “Distinct ethnic differences in lipid profiles across glucose categories,”
    40. (2011). W e n t z e n s e n ,L .M i r a b e l l o ,R .M .P f e i ffer,
    41. (2004). W.S.Browner,A.J.Kahn,E.Zivetal.,“Thegeneticsofhuman longevity,”

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.