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Effect of Circadian Clock Gene Mutations on Nonvisual Photoreception in the Mouse

By Leah Owens, Ethan Buhr, Daniel C. Tu, Tamara L. Lamprecht, Janet Lee and Russell N. Van Gelder


Mice with outer retinal degeneration lacking cryptochromes show reduced nonvisual responses to light. This effect is not specific to cryptochromes, but is common to multiple mutations that eliminate free-running circadian rhythms. The pupillary light response is under circadian regulation

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
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Provided by: PubMed Central
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