The Vitreous Glycoprotein Opticin Inhibits Preretinal Neovascularization
An opticin null mouse was generated and analyzed. The lack of opticin promoted preretinal neovascularization in the oxygen-induced retinopathy model. Excess opticin inhibited neovessel formation, so opticin inhibits pathological angiogenesis in a dose-dependent manner
Publisher: Association for Research in Vision and Ophthalmology, Inc.
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