Leptin deﬁciency causes insulin resistance induced by uncontrolled diabetes.
Leptin impairs insulin signaling in rat adipocytes.
(1997). Leptin impairs metabolic actions of insulin in isolated rat adipocytes.
(1999). Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.
Leptin-replacement therapy for lipodystrophy.
(2009). Leptin: a pivotal regulator of human energy homeostasis.
(2011). Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women.
(1992). Metformin normalizes nonoxidative glucose metabolism in insulin-resistant normoglycemic ﬁrst-degree relatives of patients with NIDDM. Diabetes
(2010). Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects. Obes Surg
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptindeﬁcient adults.
Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic proﬁle in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.
(1996). Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes
Reproducibility of glucose, fatty acid and VLDL kinetics and multi-organ insulin sensitivity in obese subjects with nonalcoholic fatty liver disease. Int J Obes.
(1996). Speciﬁcity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice.
The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inﬂammatory status in obese subjects.
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeﬁciency virus-associated lipoatrophy and hypoleptinemia.