Location of Repository

Hematopoietic Cell Transplant and Use of Massage for Improved Symptom Management: Results from a Pilot Randomized Control Trial

By Wolf E. Mehling, E. Anne Lown, Christopher C. Dvorak, Morton J. Cowan, Biljana N. Horn, Elizabeth A. Dunn, Michael Acree, Donald I. Abrams and Frederick M. Hecht

Abstract

Background. Pediatric hematopoietic cell transplant (HCT) is a lifesaving treatment that often results in physical and psychological discomfort. An acupressure-massage intervention may improve symptom management in this setting. Methods. This randomized controlled pilot trial compared a combined massage-acupressure intervention to usual care. Children were offered three practitioner-provided sessions per week throughout hospitalization. Parents were trained to provide additional acupressure as needed. Symptoms were assessed using nurses' reports and two questionnaires, the behavioral affective and somatic experiences scale and the Peds quality of life cancer module. Results. We enrolled 23 children, ages 5 to 18. Children receiving the intervention reported fewer days of mucositis (Hedges' g effect size ES = 0.63), lower overall symptom burden (ES = 0.26), feeling less tired and run-down (ES = 0.86), having fewer moderate/severe symptoms of pain, nausea, and fatigue (ES = 0.62), and less pain (ES = 0.42). The intervention group showed trends toward increasing contentness/serenity (ES = +0.50) and decreasing depression (ES = −0.45), but not decreased anxiety (ES = +0.42). Differences were not statistically significant. Discussion. Feasibility of studying massage-acupressure was established in children undergoing HCT. Larger studies are needed to test the efficacy of such interventions in reducing HCT-associated symptoms in children

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3292254
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2001). A meaningful relief from suffering: experiences of massage in cancer care,”
    2. (2004). A meta-analysis of massage therapy research,”
    3. (2007). A progress study of 100 cancer patients treated by acupressure for chemotherapyinduced vomiting after failure with the pharmacological approach,”
    4. (2004). A.E.K azak,M.Alde rfe r ,M.T .R ourk e,S.S imms,R.Str
    5. (2000). Acupressure for nausea: results of a pilot study,”
    6. (2006). Acupuncture for nausea and vomiting: an update of clinical and experimental studies,”
    7. (2006). Acupuncturepoint stimulation for chemotherapy-induced nausea or vomiting,”
    8. (2003). American Massage Therapy Association, “Member survey
    9. (1994). American Psychiatric Association, DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association,
    10. (1995). An evaluation of the use of massage and essential oils on the wellbeing of cancer patients,”
    11. (2004). Aromatherapy and massage for symptom relief in patients with cancer,”
    12. (1999). Assessment of health-related quality of life in acute in-patientEvidence-Based Complementary and Alternative Medicine 9 settings: use of the bases instrument in children undergoing bone marrow transplantation,”
    13. (1993). Autologous bone marrow transplant in acute myeloid leukemia in first remission,”JournalofClinicalOncology,vol.11,no.2,pp.314– 319,
    14. (1997). Bone marrow transplantation in pediatric oncology,”inPrinciplesandPracticeofPediatricOncology,P .A.
    15. (2004). Breast cancer patients have improved immune and neuroendocrine functionsfollowingmassagetherapy,”JournalofPsychosomatic
    16. (2004). C a s s i l e t ha n dA .J .V i c k e r s ,“ M a s s a g et h e r a p yf o r symptom control: outcome study at a major cancer center,”
    17. (2009). C h a o ,A .L .Z h a n g
    18. (2006). Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting,”
    19. (2008). Complementary and alternative therapy use in adult survivors of childhood cancer: a report from the childhood cancer survivor study,” Pediatric Blood and Cancer,
    20. (2010). Complementary therapies for children undergoing stem cell transplantation: report of a multisite trial,”
    21. (2006). Development of a taxanomy to descirbe massage treatments for musculoskeletal pain,”
    22. (2004). Effect of acupressure on nausea and vomiting during chemotherapy cycle for Korean postoperative stomach cancer patients,”
    23. (2009). Effects of a full-body massage on pain intensity, anxiety, and physiological relaxation in Taiwanese patients with metastatic bone pain: a pilot study,” J o u r n a lo fP a i na n d Symptom Management,
    24. (2005). Evidence-based interventions for survivors of childhood cancer and their families,”
    25. (2009). Exploring integrative medicine for back and neck pain—a pragmatic randomised clinical pilot trial,”
    26. (2008). Family caregivers’ strains: comparative analysis of cancer caregiving with dementia, diabetes, and frail elderly caregiving,”
    27. (1985). Family influences on hopelessness among children early in the cancer experience,”
    28. (2000). Foot massage: a nursing intervention to modify the distressing symptoms of pain and nausea in patients hospitalized with cancer,”
    29. (2007). Hong et al., “Electro-acupuncture at acupoint ST36 reduces inflammation and regulates immune activity in collagen-induced arthritic mice,”
    30. (2009). Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer,”
    31. (2008). K u t n e r ,M .C .S m i t h ,L .C o r b i ne ta l . ,“ M a s s a g et h e r a p y versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial,”
    32. (2009). Light pressure massage for patients with severe anxiety,”
    33. (1986). Longitudinal evaluations of pyschological distress in parents of children with malignancies,”
    34. (2010). Massage for children undergoing heematopoietic cell transplantation: a qualitative report,” in American Massage Therapy Association,
    35. (2008). Massage modalities and symptoms reported by cancer patients: narrative review,”
    36. (2011). Massage provides symptom relief for pediatric stem cell transplant patients: a pilot randomized controlled trial,”
    37. (2007). Massage relievesnauseainwomenwithbreastcancerwhoareundergoing chemotherapy,”
    38. (1995). Massage therapy for infants and children,”
    39. (1999). Massage therapy for patients undergoing autologous bone marrow transplantation,”
    40. (2002). Massage therapy,”
    41. (1999). Massaged embodiment of cancer patients,”
    42. (1994). Measurement of behavioral, affective, and somatic responses to pediatric bone marrow transplantation:
    43. (2006). Meta-analysis of the factor structures of four depression questionnaires: Beck, CES-D,
    44. (2006). Metaanalysis of acustimulation effects on postoperative nausea and vomiting in children,”
    45. (2008). o n e s ,S .I s o m ,K .J .K e m p e r ,a n dT .W .M c L e a n ,“ A c u -pressure for chemotherapy-associated nausea and vomiting in children,”
    46. (2009). o s t - W h i t e ,M .F i t z g e r a l d ,K .S a v i k
    47. (1981). of Traditional Medicine, Acupuncture, A Comprehensive Text,
    48. (1993). Parental psychopathology and children’s adjustment to leukemia,”
    49. (2005). Posttraumatic stress symptoms and distress among parents of children with cancer,” Children’s Health Care,
    50. (2008). Posttraumatic stressdisorderamongparentsofchildrenoncancertreatment: a longitudinal study,”
    51. (2000). Predictors of distress in parents of children with cancer: a prospective study,”
    52. (1997). Predictors of posttraumatic stress symptoms in childhood cancer survivors,”
    53. (2007). Randomized controlled trials of pediatric massage: a review,”
    54. (1996). Reciprocal influences in family adjustment to childhood cancer,”
    55. (2002). Reduction of distress associated with paediatric bone marrow transplant: complementary health promotion interventions,”
    56. (1993). Reliability and validity of a brief instrument for assessing post-traumatic stress disorder,”
    57. (2005). Safety and efficacy of massage therapy for patients withcancer,”Cancer Control,
    58. (2007). Symptom management with massage and acupuncture in postoperative cancer patients: a randomized controlled trial,” J o u r n a lo fP a i na n d Symptom Management,
    59. (2008). Systematic review of massage intervention for adult patients with cancer: a methodological perspective,”
    60. (1977). The CES-D scale: a self-report depression scale for research in the general population,”
    61. (2008). The effectiveness of the training and support program for parents of children with disabilities: a randomized controlled trial,”
    62. (1987). The family’s adaptation to childhood leukemia,”
    63. (1989). The Foundations of Chinese Medicine: A Comprehensive Text for Acupouncturists and Herbalists,
    64. The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial,”
    65. (2004). The PedsQL in pediatric cancer pain: a prospective longitudinal analysis of pain and emotional distress,”
    66. (2002). The PedsQL in pediatric cancer: reliability and validity of the pediatric quality of life inventory generic core scales, multidimensional fatigue scale, and cancer module,”
    67. (2005). The psychological well-being and self-efficacy of carers of children with disabilities following attendance on a simple massage training and support programme: a 12-month comparison study of adherers and non-adherers,”
    68. (2007). The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs,” Cancer Treatment Reviews,
    69. (2007). The training & support programme for parents of children with ataxia: a pilot study,”
    70. (1993). The use of therapeutic massage as a nursing intervention to modify anxiety and the perception of cancer pain,”
    71. (2002). Therapeutic effects of massage therapy and handling touch on caregivers of patients undergoing autologous hematopoietic stem cell transplant,” Oncology Nursing Forum,
    72. (2003). Therapeutic massage and healing touch improve symptoms in cancer,”
    73. (2004). Trauma, posttraumatic stress disorder, and health status,” in Trauma and Health, Physical Health Consequences of Exposure to Extreme Stress,
    74. (2001). What good are positive emotions in crises? A prospective study of resilience and emotions following the terrorist attacks on the United States on

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.