Location of Repository

Are Toll-like receptor gene polymorphisms associated with prostate cancer?

By Anton G Kutikhin and Arseniy E Yuzhalin

Abstract

The suggestion that there is a connection between chronic intraprostatic inflammation and prostate cancer was declared some years ago. As Toll-like receptors (TLRs) are the key players in the processes of chronic intraprostatic inflammation, there is a hypothesis that TLR gene polymorphisms may be associated with prostate cancer risk. Although a number of comprehensive studies have been conducted on large samples in various countries, reliable connections between these single nucleotide polymorphisms and prostate cancer risk, stage, grade, aggressiveness, ability to metastasize, and mortality have not been detected. Results have also varied slightly in different populations. The data obtained regarding the absence of connection between the polymorphisms of the genes encoding interleukin-1 receptor-associated kinases (IRAK1 and IRAK4) and prostate cancer risk might indicate a lack of association between inherited variation in the TLR signaling pathway and prostate cancer risk. It is possible to consider that polymorphisms of genes encoding TLRs and proteins of the TLR pathway also do not play a major role in the etiology and pathogenesis of prostate cancer. Feasibly, it would be better to focus research on associations between TLR single nucleotide polymorphisms and cancer risk in other infection-related cancer types

Topics: Commentary
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:3284260
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2010). A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications. Curr Pharm Des.
    2. (2007). Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer. Cancer Epidemiol Biomarkers Prev.
    3. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II.
    4. Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.
    5. (2007). Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet.
    6. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis.
    7. (2010). Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk: results based on pooled analysis from three independent studies. Cancer Epidemiol Biomarkers Prev.
    8. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.
    9. (2011). Sequence variants of Toll-like receptor 4 (TLR4) and the risk of prostate cancer in Korean men. World J Urol. Epub
    10. (2005). Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer. Cancer Res.
    11. (2004). Sequence variants of Toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Res.
    12. The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men.
    13. (2007). Toll-like receptor 4 genetic variation and advanced prostate cancer risk. Cancer Epidemiol Biomarkers Prev.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.