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Large Cell Neuroendocrine Carcinoma of the Thymus: A Two-Case Report

By Yong Han Yoon, Jae Ho Kim, Kwang Ho Kim, Wan Ki Baek, Hyun Kyu Lee, Moon Hee Lee, Kyung Hee Lee and Lucia Kim


A large cell neuroendocrine carcinoma (LCNEC) of the thymus is a very rare malignant tumor that has a very poor prognosis. The detailed clinical features of LCNEC are still unknown, including the long term prognoses and the definitive modalities of the treatment for LCNEC of the thymus. We are reporting 2 cases of an enlarged LCNEC of the thymus, both of which were diagnosed and treated by surgical resection followed by postoperative adjuvant chemoradiation therapy. Although recurrences and metastases of the LCNEC were noticed 1 and 4 years postoperatively for each case, aggressive surgical resection and adjuvant chemoradiation therapy may be helpful for a patient's long term survival

Topics: Case Report
Publisher: Korean Society for Thoracic and Cardiovascular Surgery
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Provided by: PubMed Central

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