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Catechol-O-methyltransferase: potential relationship to idiopathic hypertension

By Kirk J. Mantione, Richard M. Kream and George B. Stefano


Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Accordingly, homeostasis of COMT gene expression is hypothesized to be functionally linked to regulation of autonomic control of normotensive vascular events. Recently, we demonstrated that morphine administration in vitro resulted in decreased cellular concentrations of COMT-encoding mRNA levels, as compared to control values. In contrast, cells treated with E up regulated their COMT gene expression. In sum, these observations indicate a potential reciprocal linkage between end product inhibition of COMT gene expression by E and morphine. Interestingly, the observed effects of administered E on COMT gene expression suggest an enhancement of its own catabolism or, reciprocally, a stimulation morphine biosynthesis

Topics: Review Paper
Publisher: Termedia Publishing House
OAI identifier: oai:pubmedcentral.nih.gov:3282503
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    1. (2007). A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multilineage progenitor cells.
    2. (1996). A rapid and sensitive quantitation method of endogenous morphine in human plasma. Life Sci
    3. (2003). A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats.
    4. (1970). Alcohol addiction and tetrahydropapaveroline. Science
    5. (2007). alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis. Med Sci Monit
    6. (1997). Alcohol induces formation of morphine precursors in the striatum of rats. Life Sci
    7. (2006). Alcohol-, nicotine, and cocaine-evoked release of morphine from inver -tebrate ganglia: Model system for screening drugs of abuse. Med Sci Monit
    8. (1970). amines and alkaloids: a possible biochemical basis for alcohol addiction. Science
    9. (1970). an alkaloid derivative of dopamine formed in vitro during alcohol metabolism. Nature
    10. (1990). Anatomical "circuitry" in the brain mediating alcohol drinking revealed by THP-reactive sites in the limbic system. Alcohol
    11. (2006). and cocaine-evoked release of morphine from human white blood cells: substances of abuse actions converge on endogenous morphine release. Med Sci Monit
    12. (2008). Anticipatory stress response: a significant commonality in stress, relaxation, pleasure and love responses. Med Sci Monit
    13. (2009). Association between COMT gene and Chinese male schizophrenic patients with violent behavior. Med Sci Monit
    14. (1970). Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro.
    15. (2009). Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by noncovalent mass spectrometry. Med Sci Monit
    16. (2009). Comparative aspects of endogenous morphine synthesis and signaling in animals.
    17. (2008). Converging cellular processes for substances of abuse: endogenous morphine. Neuro Endocrinol Lett
    18. (2006). De novo biosynthesis of morphine in animal cells: an evidence-based model. Med Sci Monit
    19. (2008). Does COMT val158met affect behavioral phenotypes: yes, no, maybe? Neuropsychopharmacology
    20. (2008). Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo.
    21. (2004). Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains. Neurotoxicology
    22. (1999). Effect of ethanol on (R)- and (S)-salsolinol, salsoline, and THP in the nucleus accumbens of AA and ANA rats. Alcohol
    23. (1979). Effects of catecholic tetrahydroisoquinolines on endogenous catecholamines. Curr Alcohol
    24. (1991). Effects of tetrahydro -papaveroline in the nucleus accumbens and the ventral tegmental area on ethanol preference in the rat. Alcohol
    25. (2004). Endogenous formation of morphine in human cells.
    26. (2009). Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes. Med Sci Monit
    27. (1997). Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response?
    28. (2008). Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition. Addict Biol
    29. (2007). Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution.
    30. (2009). Estrogen-like endocrine disrupting chemicals affecting puberty in humans – a review. Med Sci Monit
    31. (1983). Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects. Psychopharmacology (Berl)
    32. (1983). Ethanol preference in rats: increased consumption after intraventricular administration of tetrahydropapaveroline. Neuropharmacology
    33. (1996). Evidence for morphine downregulating immunocytes during cardiopulmonary bypass in a porcine model.
    34. (1997). Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland. Pharmacogenetics
    35. (1997). High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson’s disease. Neurosci Lett
    36. (2008). Homeopathic ethanol. Med Sci Monit
    37. (2005). How human neuroblastoma cells make morphine.
    38. (2000). Human vascular and cardiac endothelia express mu opiate receptor transcripts. Endothelium
    39. (2005). Human white blood cells synthesize morphine: CYP2D6 modulation.
    40. (2008). Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. Med Sci Monit
    41. (2003). Molecular identification and functional expression of mu3, a novel alternatively spliced variant of the human mu opiate receptor gene.
    42. (2008). Mutations in human monoamine-related neurotransmitter pathway genes. Hum Mutat
    43. (2008). Nasal nitric oxide assessment in primary ciliary dyskinesia using aspiration, exhalation, and humming. Med Sci Monit
    44. (1981). Possible steady-state concentrations of tetrahydroisoquinolines in brain after the consumption of ethanol. Fed Proc
    45. (2001). Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue.
    46. (1995). Presence of the mu3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation.
    47. (2001). Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells. Med Sci Monit
    48. (2010). Regulation of the transcription of the catechol-Omethyltransferase gene by morphine and epinephrine. Activitas Nervosa Superior Rediviva
    49. (1978). Relationship between 3,4-dihydroxyphe -nylacetaldehyde levels and tetrahydropapaveroline formation. Alcohol Clin Exp Res
    50. (2009). Revisiting tolerance from the endogenous morphine perspective. Med Sci Monit
    51. (1999). Tetrahydropapaveroline injected in the ventral tegmental area shifts dopamine efflux differentially in the shell and core of nucleus accumbens in high-ethanol-preferring (HEP) rats. Alcohol
    52. (1970). Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.
    53. (1974). Tetrahydropapaveroline: formation in vivo and in vitro in rat brain. Life Sci
    54. (2010). The neurobiology of stress manage -ment. Neuro Endocrinol Lett
    55. (2001). The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Res Rev
    56. (2010). Variations in critical morphine biosynthesis genes and their potential to influence human health. Neuro Endocrinol Lett
    57. (2009). Xenobiotic perturbation of endogenous morphine signaling: paradoxical opiate hyperalgesia. Med Sci Monit

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