Location of Repository

The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres

By Mar Carmena, Xavier Pinson, Melpi Platani, Zeina Salloum, Zhenjie Xu, Anthony Clark, Fiona MacIsaac, Hiromi Ogawa, Ulrike Eggert, David M. Glover, Vincent Archambault and William C. Earnshaw

Abstract

INCENP acts as a protein scaffold that integrates the functions of two crucial mitotic kinases, Aurora B and Polo, at centromeres of mitotic chromosomes

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3265468
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2011). A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.
    2. Archambault V,GloverDM(2009) Polo-likekinases:conservationand divergence in their functions and regulation.
    3. (2002). Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation.
    4. (2010). Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.
    5. (2005). Aurora-A site specificity: a study with synthetic peptide substrates.
    6. (2010). Binucleine 2, an isoform-specific inhibitor of drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
    7. (2009). Bioimage informatics for experimental biology.
    8. (2008). Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry.
    9. (2004). Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.
    10. (2001). Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation.
    11. (2007). Chromosomal passengers: conducting cell division.
    12. (1991). Chromosomal passengers: toward an integrated view of mitosis.
    13. (2006). Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.
    14. (2006). Desai A
    15. (2006). Direct observation of individual endogenous protein complexes in situ by proximity ligation.
    16. (2002). Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.
    17. (2001). Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis.
    18. (1998). Drosophila polo kinase is required for cytokinesis.
    19. (2001). Essential roles of Drosophila inner centromere protein (INCENP) and Aurora-B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
    20. (2002). Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome biorientation by altering kinetochore-spindle pole connections.
    21. (2003). Exploring the functional interactions betweenAuroraB,INCENP,andsurvivininmitosis.MolBiolCell14:3325–3341.
    22. (2011). Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.
    23. (2005). Getting in and out of mitosis with Polo-like kinase-1.
    24. (2010). Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.
    25. (2006). INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
    26. (2006). INCENP at the kinase crossroads.
    27. (2000). INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.
    28. (2007). KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.
    29. (2006). Kinetochore microtubule dynamics and attachment stability are regulated by hec1.
    30. (2009). Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.
    31. (2006). NudC is required for Plk1 targeting to the kinetochore and chromosome congression.
    32. (2004). Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
    33. (2002). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.
    34. (2002). Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
    35. (2008). Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
    36. (2008). Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.
    37. (2008). Polo on the rise—from mitotic entry to cytokinesis with Plk1.
    38. (2009). Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS One 4:
    39. (2008). Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
    40. (1988). Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.
    41. (2010). promotes timely formation of kinetochoremicrotubule attachments.
    42. (2007). Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex.
    43. (2006). Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
    44. (2009). Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.
    45. (2010). Spatiotemporal composition of the mitotic Chromosomal Passenger Complex detected using in situ proximity ligation assay. Mol Oncol.
    46. (2007). stability of kinetochore microtubule interactions.
    47. (2010). Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.
    48. (2009). The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
    49. (1987). The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.
    50. (2009). The Nup107–160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex.
    51. (2010). The Plk1-dependent phosphoproteome of the early mitotic spindle.
    52. (2007). The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of pololike kinase 1.
    53. (2010). Two histone marks establish the inner centromere and chromosome bi-orientation.
    54. (2007). Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.