Article thumbnail

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

By Sriparna KunduSen, Pallab K. Haldar, Malaya Gupta, Upal K. Mazumder, Prerona Saha, Asis Bala, Sanjib Bhattacharya and Biswakanth Kar


The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5 mg kg−1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property

Topics: Research Article
Publisher: International Scholarly Research Network
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2003). A .N .N a g a p p a ,P .A .T h a k u r d e s a i ,N .V .R a o ,a n dJ .S i n g h , “Antidiabetic activity of Terminalia catappa Linn fruits,”
  2. (1998). A.KaulandK.L.Khanduja,“Polyphenolsinhibitpromotional phase of tumorigenesis: relevance of superoxide radicals,”
  3. (2004). Abd El Kader, “The influence of naringin on the oxidative state of rats with streptozotocin-induced acute hyperglycaemia,” Zeitschrift fur Naturforschung.
  4. (2010). Antidiabetic activity and modulation of antioxidant status by Sansevieria roxburghiana rhizome in streptozotocininduceddiabeticrats,”DiabetologiaCroatica,v ol.39,no .4,p p .
  5. (2010). Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats,”
  6. (2001). Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats,”
  7. (2006). Antimicrobial effects of selected plant essential oils on the growth of aPseudomonasputidastrainisolatedfrommeat,”MeatScience,
  8. (1998). Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea,”
  9. (2007). Basdeo et al., “Perceived efficacy of herbal remedies by users accessing primary healthcare in Trinidad,”
  10. (2010). Citrus limetta leaves extract antagonizes the hypertensive effect of angiotensin II,”
  11. (1994). Citrus limetta,” in Atlas de las Plantas de la Medicina Tradicional Mexicana, Instituto Nacional Indigenista,
  12. (2007). Determination of new retention indices for quick identification of essential oils compounds,”
  13. (2010). Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats,”
  14. (2002). Effect of chronic treatment with Enicostemma littorale in non-insulindependent diabetic (NIDDM) rats,”
  15. (1986). Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocininduced diabetes,”
  16. (1995). Estudio Etnobot´ anico y Fitoqu´ ımico de plantas ´ utiles en la regi´ on de Xochipala Guerrero para el tratamiento de la diabetes NID, M.S. thesis, Facultad de Ciencias,
  17. (2010). Evaluation of invitro antioxidant activity of Citrus limetta and Citrus maxima onreactive oxygenand nitrogenspecies,”
  18. (2002). Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats,”
  19. (2006). Flavonoid composition of fruit tissues of citrus species,”
  20. (2008). for the Testing of Chemicals: Test No. 420: Acute Oral Toxicity: Fixed Dose Procedure,
  21. (1998). Fruit hydroxycinnamic acids inhibit human low-density lipoprotein oxidation in vitro,”
  22. (2003). G¨ o k s e l ,a n dH .H .H a t e m i ,“ H y p o -glycemic activity of Urtica pilulifera instreptozotocin-diabetic rats,”
  23. (1997). Herbal medicine,” in The Management by Indigenous Resources,
  24. (2007). Hypoglycemic effect of Treculia africana decne root bark in normal and alloxan-induced diabetic rats,”
  25. (1981). Lipid peroxidation measured as TBARS in tissue characterization and comparison with homogenates and microsomes,”
  26. (2001). Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses,”
  27. Plantas medicinales caribe˜ nas con potencialidad para inhibir la agregaci´ on de las plaquetas,” Revista Cubana de Plantas Medicinales,
  28. (2010). Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel,”
  29. (1994). Potential dietary benefits of citrus pectin and fiber,”
  30. (1991). R.R.HolmanandR.C.Turner,“Oralagentsandinsulininthe treatment of NIDDM,” in Text Book of Diabetes,J .P i c k u pa n d G.
  31. (2000). Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin,”
  32. (1996). Screening for inhibitory activity of citrus fruit extracts against platelet cyclooxygenase and lipoxygenase,”
  33. (1983). Textbook of Pharmacognosy,
  34. (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,”
  35. (2004). The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice,”
  36. (1959). Tissue sulfhydryl groups,”
  37. (2001). u s t ,H .S i e s ,W .S t a h l ,a n dM .C .P o l i d o r i ,“ A n a l y s i so f lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids,”
  38. (2006). X u ,P .D .F r a s e r ,W .J .W a n g ,a n dP .M .B r a m l e y , “Differences in the carotenoid content of ordinary citrus and lycopene-accumulating mutants,”

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.