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fMRI Investigation of Cortical and Subcortical Networks in the Learning of Abstract and Effector-Specific Representations of Motor Sequences

By Dr. Raju S. Bapi, Mr. K. P. Miyapuram, Dr. F. X. Graydon and Dr. Kenji Doya


A visuomotor sequence can be learned as a series of visuo-spatial cues or as a sequence of effector movements. Earlier imaging studies have revealed that a network of brain areas is activated in the course of motor sequence learning. However these studies do not address the question of the type of representation being established at various stages of visuomotor sequence learning. In an earlier behavioral study, we demonstrated that acquisition of visuo-spatial sequence representation enables rapid learning in the early stage and progressive establishment of somato-motor representation helps speedier execution by the late stage. We conducted functional magnetic resonance imaging (fMRI) experiments wherein subjects learned and practiced the same sequence alternately in normal and rotated settings. In one rotated setting (visual), subjects learned a new motor sequence in response to an identical sequence of visual cues as in normal. In another rotated setting (motor), the display sequence was altered as compared to normal, but the same sequence of effector movements were used to perform the sequence. Comparison of different rotated settings revealed analogous transitions both in the cortical and subcortical sites during visuomotor sequence learning  a transition of activity from parietal to parietal-premotor and then to premotor cortex and a concomitant shift was observed from anterior putamen to a combined activity in both anterior and posterior putamen and finally to posterior putamen. These results suggest a putative role for engagement of different cortical and subcortical networks at various stages of learning in supporting distinct sequence representations

Topics: Brain Imaging
Year: 2006
DOI identifier: 10.1016/j.neuroimage.2006.04.205
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  1. (1998). A neuropsychological theory of motor skill learning. doi
  2. (1998). Abstract and effector-specific representations of motor sequences identified with PET.
  3. (1996). Activation of human presupplementary motor area in learning of sequential procedures: a functional MRI study.
  4. (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fmri data sets.
  5. (1997). Anatomy of motor learning. I. Frontal cortex and attention to action.
  6. (2000). Automated Talairach atlas labels for functional brain mapping.
  7. (2002). Central mechanisms of motor skill learning.
  8. (2003). Chunking during human visuomotor sequence learning.
  9. (2004). Chunking Phenomenon in Complex Sequential Skill Learning in Humans. In
  10. (1988). Co-planar stereotaxic atlas of the human brain.
  11. (1994). Correlation, regression, and repeated data.
  12. (2003). Distinct contribution of the corticostriatal and cortico-cerebellar systems to motor skill learning.
  13. (2002). Dynamic cortical and subcortical networks in learning and delayed recall of timed motor sequences.
  14. (2000). Evidence for effector independent and effector dependent representations and their differential time course of acquisition during motor sequence learning.
  15. (2002). Fast robust automated brain extraction.
  16. (1995). Functional mapping of sequence learning in normal humans.
  17. (1998). Generalisability, random effects and population inference.
  18. (1995). Learning of sequential movements in the monkey: Process of learning and retention of memory.
  19. (1994). Motor sequence learning: A study with positron emission tomography.
  20. (2003). Neocortical mechanisms in motor learning.
  21. (1983). Object vision and spatial vision: Two cortical pathways.
  22. (2001). Parallel cortico basal ganglia mechanisms for acquisition and execution of visuomotor sequences – a computational approach.
  23. (1999). Parallel neural networks for learning sequential procedures.
  24. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
  25. (1964). Perceptual-motor skill learning. In A.W. Melton (ed), Categories of human learning.
  26. (1997). Premotor and parietal cortex: Corticocortical connectivity and combinatorial computations. doi
  27. (2003). Random effects analysis. In
  28. (1996). Role for cells in the presupplementary motor area in updating motor plans.
  29. (1994). Role of supplementary motor areas cells in planning several movements ahead. doi
  30. (2001). Sequential organization of multiple movements: Involvement of cortical motor areas.
  31. (1995). Spatial registration and normalisation of images.
  32. (2000). Specialized neural systems underlying representations of sequential movements.
  33. (1995). Statistical parametric maps in functional imaging: A general linear approach.
  34. (2000). Stereotaxic display of brain lesions.
  35. (1995). The cerebellum as a sensory acquisition controller.
  36. (1998). The time course of changes during motor sequence learning: a whole-brain fMRI study. doi
  37. (1998). Transition of brain activation from frontal to parietal areas in visuomotor sequence learning.
  38. (2001). Using the Talairach atlas with the MNI template.
  39. (1998). Visuomotor transformations: Early cortical mechanisms of reaching.
  40. when–parallel and convergent processing in motor control.