(2002). Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. Life Sciences
(2008). Arsenic-based antineoplastic drugs and their mechanisms of action. Met Based Drugs
(1998). Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science
(2005). C: A phase II trial of arsenic trioxide in patients with metastatic melanoma. Cancer
(2007). CB: Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci
(2008). CJ: Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate
(2004). Cuezva JM: Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.
(2010). Cuezva JM: Selection of cancer cells with repressed mitochondria triggers colon cancer progression. Carcinogenesis
(1997). Dang CV: c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth. Proc Natl Acad Sci USA
(2006). Dang CV: Cancer’s molecular sweet tooth and the Warburg effect. Cancer Res
(2008). De Vivo I: Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol
(2011). Denko NC: Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
(2009). Denko NC: Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One
(2010). DL: Sodium Dichloroacetate (DCA) selectively targets cells with defects in the mitochondrial ETC.
(2007). et al: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell
(2010). et al: Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood
(2000). et al: Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia
(2010). et al: Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med
(1997). et al: Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood
(1999). G: Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp Cell Res
(2002). Generation of reactive oxygen species by the mitochondrial electron transport chain.
(2003). Germano I: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res
(1999). Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res
(2007). Hogg PJ: Arsenical-based cancer drugs. Cancer Treat Rev
(2002). Holbrook NJ: Cellular response to oxidative stress: Signaling for suicide and survival.
(2005). Huang X: mCICR is required for As2O3-induced permeability transition pore opening and cytochrome c release from mitochondria. Mol Cell Biochem
(2001). Introduction: the history of arsenic trioxide in cancer therapy. Oncologist
(2001). Kakizuka A: Tumor Growth Inhibition by Arsenic Trioxide (As2O3) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer. Cancer Res
(2000). KN: Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood
(1993). Lightowlers RN: A microtiter plate assay for cytochrome c oxidase in permeabilized whole cells. Analytical Biochemistry
(1998). Mitochondria as regulators of apoptosis: Doubt no more. Biochimica et Biophysica Acta - Bioenergetics
(1926). Negelein E: Ueber den Stoffwechsel von Tumoren im körper. Klinische Wochenschrift
(2009). PG: Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta. Biochem Pharmacol
(2004). Q: Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene
(2003). Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity. Chem Res Toxicol
(1999). Redox regulation of cellular signalling. Cellular Signalling
(2009). Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol
(2004). ROS stress in cancer cells and therapeutic implications. Drug Resist Updat
(1996). S: The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A. Science
(2010). SD: Arsenic trioxide - An old drug rediscovered. Blood Rev
(2004). SX: Effect of arsenic trioxide on human hepatocarcinoma in nude mice.
(2006). The c-Myc target gene network. Seminars in Cancer Biology
(2007). YC: Survivin mediates the antiapoptotic effect of δ-opioid receptor stimulation in cardiomyocytes.