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Assessment of Epidermal Growth Factor Receptor and K-Ras Mutation Status in Cytological Stained Smears of Non-Small Cell Lung Cancer Patients: Correlation with Clinical Outcomes

By Maria D. Lozano, Javier J. Zulueta, Jose I. Echeveste, Alfonso Gúrpide, Luis M. Seijo, Salvador Martín-Algarra, Anabel del Barrio, Ruben Pio, Miguel Angel Idoate, Tania Labiano and Jose Luis Perez-Gracia


EGFR and K-ras mutation status was determined from tumor DNA extracted from cytological samples from non-small cell lung cancer patients, with results comparable with those from biopsy samples. Clinical outcomes of patients harboring mutations and their response to tyrosine kinase inhibitor therapy are also discussed

Topics: Lung Cancer
Publisher: AlphaMed Press
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Provided by: PubMed Central
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