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Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older

By L. Ersoy, T. Ristau, M. Hahn, M. Karlstetter, T. Langmann, K. Droge, A. Caramoy, A.I. den Hollander and S. Fauser


PURPOSE: We studied associations of genetic polymorphisms in age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) in nonagenarians with age-related macular degeneration (AMD). METHODS: This case-control study comprised 2737 persons (1204 controls, 1433 AMD cases), including 166 nonagenarians (52 controls, 114 AMD cases). Single nucleotide polymorphisms (SNPs) in the genes ARMS2 and CFH were determined. Risk scores were computed by multiple logistic regression analysis, including genetic and environmental risk factors (smoking, hypertension, body mass index, diabetes) for different age groups (/=90 years [nonagenarians]). RESULTS: In nonagenarians, ARMS2 showed the weakest associations with AMD (odds ratio [OR] = 1.52, P = 0.127) compared to the other groups (OR, 70 years = 2.23, P = 1.03 x 10(-13); OR, 70-79 years = 2.70, P = 1.00 x 10(-13); OR, 80-89 years = 3.11, P = 6.56 x 10(-8)). For CFH, ORs for AMD increased with age (90 years = 0.608). CONCLUSIONS: Risk alleles in CFH and ARMS2 have a significantly smaller effect on AMD development in nonagenarians, while environmental factors retain a similar effect

Publisher: 'Association for Research in Vision and Ophthalmology (ARVO)'
Year: 2014
DOI identifier: 10.1167/iovs.13-13420
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Provided by: NARCIS
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