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Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients

By Gert-Jan Braunstahl, Alex Kleinjan, Shelley Overbeek, Jan-Bas Prins, Henk Hoogsteden and Wytske Fokkens


Allergic rhinitis and asthma often coexist and share a genetic background. Pathophysiologic connections between the nose and lungs are still not entirely understood. This study was undertaken to compare allergic inflammation and clinical findings in the upper and lower airways after segmental bronchial provocation (SBP) in nonasthmatic allergic rhinitis patients. Eight nonasthmatic, grass pollen-sensitive patients with allergic rhinitis and eight healthy controls were included. Bronchial biopsies and blood samples were taken before (T(0)) and 24 h (T(24)) after SBP. Nasal biopsies were obtained at T(0), 1 h after SBP (T(1)), and T(24). Immunohistochemical staining was performed for eosinophils (BMK13), interleukin (IL)-5, and eotaxin. The number of eosinophils increased in the challenged and unchallenged bronchial mucosa (p < 0.05) and in the blood (p = 0.03) of atopic subjects at T(24). We detected an increase of BMK13-positive and eotaxin-positive cells in the nasal lamina propria and enhanced expression of IL-5 in the nasal epitheliu

Topics: *Bronchial Provocation Tests, *Chemokines, CC, Adult, Asthma/diagnosis/immunology, Biopsy, Cytokines/metabolism, Eosinophils/immunology, Female, Humans, Interleukin-5/metabolism, Leukocyte Count, Male, Nasal Mucosa/*immunology/pathology, Research Support, Non-U.S. Gov't, Rhinitis, Allergic, Seasonal/diagnosis/*immunology, Risk Factors
Year: 2000
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Provided by: NARCIS
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