Skip to main content
Article thumbnail
Location of Repository

Issues in QT interval measurement

By Pallavi Lanjewar, Vaishali Pathak and Yash Lokhandwala

Abstract

The QT interval, apart from clinical implications is crucial for safety assessment of new drugs under development. A QTc prolongation of even 10 msec in a study group is a warning signal for a new drug. There are various issues involved in the measurement of the QT interval especially regarding the ending of the T wave and different morphological pattern of T-U complex. The other issue is significant spontaneous variability in the QT interval, resulting in spurious QT prolongation and unnecessary concern. To minimize all these confounding factors, all clinical trials for assessing QT interval prolongation should be randomized and double blinded with appropriate control groups including placebo. ECG measurements should be done by trained readers with electronic calipers at ECG core Lab. ECGs should be compared with multiple baseline values with multiple, time-matched on-treatment values

Topics: Indian Pacing and Electrophysiology Journal
Publisher: Indian Pacing and Electrophysiology Group
Year: 2004
OAI identifier: oai:cogprints.org:4178
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/4178/1/ya... (external link)
  • http://cogprints.org/4178/ (external link)
  • Suggested articles

    Citations

    1. (2003). Accelerometer-based Body- position sensing for Ambulatory Electrocardiographic Monitoring. Biomed Instrum Technol.
    2. (2002). Accurate Evaluation of QT Interval in conscious Rhesus Monkeys by use of
    3. (2003). Ambulatory Electrocardiographic Recording. Circulation
    4. (2003). Detection of different Recumbent Body positions from the Electrocardiogram. Med Biol Eng Comput.
    5. (2004). Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods. Ann Noninvasive Electrocardiol.
    6. (1985). Gonska BD: Long-term electrocardiography: value and reliability of various systems. Z Kardiol.
    7. Lazzara R.Antiarrhythmic drugs and torsade de pointes.Eur
    8. (2002). QT interval measurements : Card Electrophysiolol Rev
    9. (1992). Should the JT rather than the QT interval be used to Detect Prolongation of Ventricular Repolarization? An Assessment in Normal Conduction and in Ventricular Conduction Defects.
    10. (1992). The importance of derived 12-lead Electrocardiography in the Interpretation of Arrhythmias detected by Holter recording. Am Heart

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.