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(R2) Antibodies: Moving Closer to Personalized Therapeutics and Diagnostics

By R. Umeck, J.E. Harlan and B.R. Curtis

Abstract

The possibilities of personalized medicine are largely rooted in successfully exploiting the ever-growing genome and proteome-wide understanding of human biology. Translating this knowledge base into the clinic requires, among other things, being able measure the patient's genomic and proteomic disease signature in a routine manner. Thus, expanded focus on assays and platforms capable of measuring these specific signatures within tens, hundreds or even thousands of complex patient samples simultaneously is critical. Antibody-based assays and platforms have become a centerpiece of many technologies pushing these boundaries because of the antibody's intrinsic specificity, diverse recognition capacity and ease with which they can be produced. Furthermore, these same characteristics have made them an equally promising prospect for therapeutic approaches. This seminar trifecta will highlight the pivotal role antibodies have in multiplex biomarker assay development and therapeutic venues. Specifically: 1. Brian Curtis will discuss a robust multiplex assay platform to detect human platelet auto-antibodies and platelet antigen polymorphisms by combining bead array technologies with flow cytometry. Such a simple, yet high-throughput platform would facilitate routine testing for platelet disorders like neonatal alloimmune thrombocytopenia, multi-platelet transfusion refractoriness, and post-transfusion purpura; 2. Robert Umeck will summarize the challenges in developing antibody-based multiplex assays and how Meso Scale Discovery utilizes an electrochemiluminescence detection system combined with a patterned multi-array format to generate multiplex assays for nearly any application. Several actual examples will be presented to demonstrate how this approach could support personalized medicine; 3. John Harlan will introduce and discuss the evolution of therapeutic antibodies. To illustrate where the field is venturing, he will highlight Abbott Laboratory's new bi-specific antibody format

Topics: Research Group Session Abstracts
Publisher: Association of Biomolecular Resource Facilities
OAI identifier: oai:pubmedcentral.nih.gov:3186540
Provided by: PubMed Central
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