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Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

By Kathryn S. Jones, Sophie Lambert, Manuella Bouttier, Laurence Bénit, Frank W. Ruscetti, Olivier Hermine and Claudine Pique

Abstract

The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage

Topics: Review
Publisher: Molecular Diversity Preservation International (MDPI)
OAI identifier: oai:pubmedcentral.nih.gov:3185769
Provided by: PubMed Central

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Citations

  1. A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response.
  2. (1997). A novel human T-leukemia virus type 1 cell-to-cell transmission assay permits definition of SU glycoprotein amino acids important for infectivity.
  3. (1998). A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes.
  4. (1998). African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies.
  5. (2009). Alternate receptor usage of neuropilin-1 and glucose transporter protein 1 by the human T cell leukemia virus type 1. Virology
  6. (1998). Analysis of functional conservation in the surface and transmembrane glycoprotein subunits of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.
  7. (2009). Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry.
  8. (2008). Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells.
  9. (2008). Common principles and intermediates of viral protein-mediated fusion: The HIV1 paradigm. Retrovirology
  10. (2005). Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2. Oncogene
  11. (1985). Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
  12. (2007). Conformation-specific antibodies targeting the trimer-of-hairpins motif of the human T-cell leukemia virus type 1 transmembrane glycoprotein recognize the viral envelope but fail to neutralize viral
  13. (2000). Cooperative subunit interactions within the oligomeric envelope glycoprotein of HIV-1: functional complementation of specific defects
  14. (2010). Current concepts regarding the HTLV-1 receptor complex. Retrovirology
  15. (2000). Definition of an amino-terminal domain of the human T-cell leukemia virus type 1 envelope surface unit that extends the fusogenic range of an ecotropic murine leukemia virus.
  16. (2005). Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. Retrovirology
  17. (2010). Endocytosis of HIV: Anything goes. Trends Microbiol.
  18. (2005). Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.
  19. (2002). Envelope proteins containing single amino acid substitutions support a structural model of the receptor-binding domain of bovine leukemia virus surface
  20. (2009). for entry by molecular mimicry of VEGF165. Blood
  21. (2007). GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1.
  22. (2005). Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells.
  23. (2006). HIV-1 coreceptors and their inhibitors.
  24. (2001). HTLV-1 structural proteins. Virus Res.
  25. (2006). Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.
  26. (2003). Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans.
  27. (1992). Human T-cell leukemia virus type I envelope protein maturation process: requirements for syncytium formation.
  28. (2006). Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein.
  29. (2008). Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon. Virology
  30. (1994). Identification of functional regions in the human T-cell leukemia virus type I SU
  31. (1992). Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1.
  32. (1994). Identification of novel neutralization-inducing regions of the human T cell lymphotropic virus type I envelope glycoproteins with human HTLV-I-seropositive sera.
  33. (2008). Identification of residues outside of the receptor binding domain that influence the infectivity and tropism of porcine endogenous retrovirus.
  34. (2006). Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter GLUT-1: Evidence using antibodies specific to the receptor's large extracellular domain. Virology
  35. Interaction between the HTLV-1 envelope and cellular proteins: impact on virus infection and restriction.
  36. (2008). Intersubunit disulfide isomerization controls membrane fusion of human T-cell leukemia virus
  37. (2006). Intrahost variations in the envelope receptor-binding domain (RBD) of HTLV-1 and STLV-1 primary isolates. Retrovirology
  38. (2004). Isomerization of the intersubunit disulphide-bond in Env controls retrovirus fusion.
  39. (2009). Lipids and membrane microdomains in HIV-1 replication. Virus Res.
  40. (1997). Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes.
  41. (2004). Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral
  42. (1992). Mapping of homologous, aminoterminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins.
  43. (2000). Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
  44. (2001). Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis.
  45. (1982). Monoclonal antibodies define eight independent antigenic regions on the bovine leukemia virus (BLV) envelope glycoprotein gp51. Virology
  46. (2002). Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus.
  47. (1993). Multiple neutralizing B-cell epitopes of human T-cell leukemia virus type 1 (HTLV-1) identified by human monoclonal antibodies. A basis for the design of an HTLV-1 peptide
  48. (1997). Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell
  49. (1998). Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell
  50. (2009). Neuropilin-1 is not a marker of human Foxp3+ Treg.
  51. (2009). Neuropilins in tumor biology. Clin. Cancer Res.
  52. (2008). Neuropilins: Structure, function and role in disease.
  53. (1990). Receptor interference groups of 20 retroviruses plating on human cells. Virology
  54. (1995). Receptor-binding domain of murine leukemia virus envelope glycoproteins.
  55. (2003). Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation. Blood
  56. (2007). Structural basis for ligand and heparin binding to neuropilin B domains.
  57. (1997). Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science
  58. (2008). The C domain in the surface envelope glycoprotein of subgroup C feline leukemia virus is a second receptor-binding domain. Virology
  59. (2003). The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis. Blood
  60. (2009). The human HTLV-3 and HTLV-4 retroviruses:
  61. (2009). The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2.
  62. (2003). The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell
  63. (2004). Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry. Blood
  64. (2007). Virus membrane fusion. FEBS Lett.