Article thumbnail

Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines

By Stanisław Boryczka, Wojciech Mól, Magdalena Milczarek, Joanna Wietrzyk and Ewa Bębenek


The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID50 values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds

Topics: Original Research
Publisher: Springer-Verlag
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening.
  2. (1999). Occurrence and significance of decahydroquinolines from dendrobatid poison frogs and a myrmicine ant: use of 1H and 13C NMR in their conformational analysis.
  3. (2002). Synthesis and cytotoxicity of 3-(hetarylothio)-1-propynyl-(trimethyl)silane. Chem Heterocycl Comp 38:867–872 Aboul-Faddl T
  4. (2010). Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline. Med Chem Res 19:551–564. doi:10.1007/s00044-009-9212-x Fakhfakh
  5. (1994). The chemistry of functional groups, supplement C2. In: Patai S (ed) The chemistry of triple bonded functional groups.