Article thumbnail

Treatment of gram-positive deep sternal wound infections in cardiac surgery -experiences with daptomycin-

By Aron F Popov, Jan D Schmitto, Ahmad F Jebran, Christian Bireta, Martin Friedrich, Direndra Rajaruthnam, Kasim O Coskun, Anselm Braeuer, Jose Hinz, Theodor Tirilomis and Friedrich A Schoendube

Abstract

The reported incidence of deep sternal wound infection (DSWI) after cardiac surgery is 0.4-5% with Staphylococcus aureus being the most common pathogen isolated from infected wound sternotomies and bacteraemic blood cultures. This infection is associated with a higher morbidity and mortality than other known aetiologies. Little is reported about the optimal antibiotic management. The aim of the study is to quantify the application of daptomycin treatment of DSWI due to gram-positive organisms post cardiac surgery

Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3184046
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2006). aureus Endocarditis and Bacteremia Study Group: Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus.
  2. (2007). Clinical experience with daptoymcin for the treatment of patients with osteomyelitis.
  3. (2006). Cortina Romero JM, Rufilanchas JJ: Case-control study of risk factors for mediastinitis after cardiovascular surgery. Infect Control Hosp Epidemiol
  4. Cubicin [prescribing information]:
  5. (2004). Daptomycin 98-01 and 99-01 Investigators. The safety and efficacy of daptomycin for the treatment of complicated skin and skinstructure infections. Clin Infect Dis
  6. (2007). Daptomycin for eradication of a systemic infection with a methicillin-resistant-Staphylococcus aureus in a biventricular assist device recipient. Ann Thorac Surg
  7. (1992). Daschner FD: Added hospital stay due to wound infections following cardiac surgery. Thorac Cardiovasc Surg
  8. (1997). E: Postsurgical mediastinitis: a case-control study. Clin Infect Dis
  9. (2008). Hospital Clinic Experimental Endocarditis Study Group: Daptomycin is effective in treatment of experimental. endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus. Antimicrob Agents Chemother
  10. (2006). Increased Vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period.
  11. (1992). Infections Surveillance (NNIS) System Report, data summary from
  12. (2006). Ingemansson R: Poststernotomy mediastinitis: a review of conventional surgical treatments, vacuum assisted closure therapy and presentation of the Lund University Hospital mediastinitis algorithm. Eur J Cardiothorac Surg
  13. (2005). JH: Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy. Antimicrob Agents Chemother
  14. (2008). Noirhomme P: Algorithm for primary closure in sternal wound infection: A single institution 10-year experience. Eur J Cardiothorac Surg
  15. (1996). Post-operative Mediastinitis: classification and management. Ann Thorac Surg
  16. (2006). Regalla DM: Uncertain efficacy of daptomycin for prosthetic joint infections: a prospective case series. Clin Orthop Relat Res
  17. (2001). Resistance studies with daptomycin. Antimicrob Agents Chemother
  18. (2010). Schoendube FA: Daptomycin as a possible new treatment option for surgical management of MethicillinResistant Staphylococcus aureus sternal wound infection after cardiac surgery. J Cardiothorac Surg
  19. (2009). Schoendube FA: Daptomycin for treatment of methicillin-resistant Staphylococcus epidermidis saphenectomy wound infection after coronary artery bypass graft operation (CABG): a case report. J Cardiothorac Surg
  20. (2004). Sternal surgical-site infection following coronary artery bypass graft: prevalence, microbiology, and complications during a 42-month period. Infect Control Hosp Epidemiol
  21. (2002). The vacuum-assisted closure system for the treatment of deep sternal wound infections after cardiac surgery. Ann Thorac Surg
  22. (2005). Use of daptomycin to treat drugresistant Gram-positive bone and joint infections. Curr Med Res Opin
  23. (2007). Vancomycin MIC creep in nonvancomycin-intermediate Staphylococcus aureus (VISA), vancomycinsusceptible clinical methicillin-resistant S. aureus (MRSA) blood isolates from 2001–05. J Antimicrob Chemother
  24. (2006). Yankelev S: A prospective, comparative study of daptomycin for the treatment of superficial and deep surgical site infections.,