Article thumbnail

Efficacy and Safety of Human Placental Extract Solution on Fatigue: A Double-Blind, Randomized, Placebo-Controlled Study

By Kang-Kon Lee, Whan-Seok Choi, Keun-Sang Yum, Sang-Wook Song, Sun-Myeong Ock, Sat-Byul Park and Moon-Jong Kim


Introduction. Fatigue is a common symptom, but only a few effective treatments are available. This study was conducted to assess the efficacy and safety of the human placental extract solution, which has been known to have a fatigue recovery effect. Methods. A total of 315 subjects were randomly assigned to three groups: group 1 (with Unicenta solution administration), group 2 (with exclusively human placental extract administration, excluding other ingredients from the Unicenta solution), and the placebo group. Subsequently, solutions were administered for four weeks. Results. The fatigue recovery rate was 71.00% in group 1, 71.72% in group 2, and 44.21% in the placebo group, which show statistically significant differences between the group 1 and the placebo group (P value = 0.0002), and between group 2 and the placebo group (P value = 0.0001). Conclusion. The human placental extract solution was effective in the improvement of fatigue

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1978). A study on the anti-fatigue of the placental extract (Melsmon) and its hormone-like application,”
  2. (1999). A study on the standardization of the hospital anxiety and depression scale for koreans: a comparison of normal, depressed and anxious groups,”
  3. (1990). An analysis of published and other available data,”
  4. (1992). Anti-inflammatoryeffectofhumanplacentalextract:abiochemicalmechanistic approach,” European Review for
  5. (1986). Comparative studies on rat primary cultured and isolated hepatocytes in the evaluation of a therapeutic agent for liver disease,”
  6. (1994). Dimensional assessment of chronic fatigue syndrome,”
  7. (1991). Fatigue in cancer patients: a descriptive study,”
  8. (2005). K i m ,S .Y .C h o i
  9. (2008). K o n g
  10. (2002). Ltryptophan as an antioxidant in human placenta extract,”
  11. (2003). The effect of placental extract on the expression of tyrosinase,