Article thumbnail

Early Hypothalamic FTO Overexpression in Response to Maternal Obesity – Potential Contribution to Postweaning Hyperphagia

By Vanni Caruso, Hui Chen and Margaret J. Morris
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3182187
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
  2. (2002). A global response to a global problem: the epidemic of overnutrition.
  3. (2010). A maternal ‘‘junk food’’ diet in pregnancy and lactation promotes nonalcoholic Fatty liver disease in rat offspring.
  4. (1993). ADD1: a novel helixloop-helix transcription factor associated with adipocyte determination and differentiation.
  5. (2008). An obesity-associated FTO gene variant and increased energy intake in children.
  6. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
  7. (2008). Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
  8. (2011). Association between the FTO gene and overweight in Japanese children and adolescents. Pediatr Diabetes.
  9. (2011). Associations between a Single Nucleotide Polymorphism of the FTO Gene (rs9939609) and Obesity-Related Characteristics over Time during Puberty in a Dutch Children Cohort.
  10. (2007). Chicken liver and muscle carnitine palmitoyltransferase 1: nutritional regulation of messengers.
  11. (2002). Childhood obesity: public-health crisis, common sense cure.
  12. (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
  13. (2011). Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly.
  14. (2005). Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.
  15. (2009). Early life influences on obesity risk – maternal overnutrition and programming of obesity.
  16. (2005). Effect of starvation on hepatic acylCoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats.
  17. (2009). Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth.
  18. (1994). Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat.
  19. (2002). Fetal programming of coronary heart disease.
  20. (2011). FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
  21. (2008). Gene-environment interactions in the etiology of obesity: defining the fundamentals.
  22. (2009). Genetics, physiology and perinatal influences in childhood obesity: view from the Chair.
  23. (2007). Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits.
  24. (2001). Hepatic mRNAs up-regulated by starvation: an expression profile determined by suppression subtractive hybridization.
  25. (1995). Hormonal and nutritional control of the fatty acid synthase promoter in transgenic mice.
  26. (2009). Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment.
  27. (2010). Hypothalamicspecific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.
  28. (2008). Impact of nine common type 2 diabetes risk polymorphisms
  29. (2010). Life course variations in the associations between FTO and MC4R gene variants and body size.
  30. (2004). Living with the past: evolution, development, and patterns of disease.
  31. (2009). Maternal and Child Obesity: The Causal Link.
  32. (2008). Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism.
  33. (2009). Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.
  34. (2009). Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression.
  35. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice.
  36. (2011). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9?1 million participants.
  37. (2003). Obesity and pregnancy–the propagation of a viscous cycle?
  38. Overexpression of Fto leads to increased food intake and results in obesity.
  39. (2010). Physiological insights gained from gene expression analysis in obesity and diabetes.
  40. (2008). Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure.
  41. (1998). Regulation of fat synthesis and adipose differentiation.
  42. (2010). Relationship between blood glucose levels and hepatic Fto mRNA expression in mice.
  43. (1993). SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
  44. (2009). The FTO gene and measured food intake in children.
  45. (2009). The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients.
  46. (2008). The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.
  47. (2007). The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
  48. (2006). The short- and long-term implications of maternal obesity on the mother and her offspring.
  49. (2009). Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
  50. (2010). Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children.
  51. (2006). Worldwide trends in childhood overweight and obesity.