Article thumbnail

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

By Yiqi Guo, Magali Audry, Michael Ciancanelli, Laia Alsina, Joana Azevedo, Melina Herman, Esperanza Anguiano, Vanessa Sancho-Shimizu, Lazaro Lorenzo, Elodie Pauwels, Paul Bastard Philippe, Rebeca Pérez de Diego, Annabelle Cardon, Guillaume Vogt, Capucine Picard, Zafitsara Zo Andrianirina, Flore Rozenberg, Pierre Lebon, Sabine Plancoulaine, Marc Tardieu, Valérie Doireau, Emmanuelle Jouanguy, Damien Chaussabel, Frederic Geissmann, Laurent Abel, Jean-Laurent Casanova and Shen-Ying Zhang

Abstract

A new autosomal recessive form of complete TLR3 deficiency reveals that human TLR3 is nonredundant in immunity against herpes simplex virus 1 in the central nervous system (CNS) but redundant in host defense against viruses outside the CNS

Topics: Article
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:3182056
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2010). Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood.
  2. (2009). Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet.
  3. (2006). Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators.