Article thumbnail

Is dementia preventable?

By Amos D. Korczyn


Dementía is an important public health problem of increasing magnitude. At present, available therapies provide only minor and temporary relief, and attempts to find a cure have so far failed. Epidemiological studies have identified risk factors for dementía, particularly Alzheimer's disease and vascular dementia. In principle, these findíngs provide an opportunity to intervene and prevent the dementía epidemic. Attention to nongenetic risk factors such as hypertension, hyperlipidemia, smoking, and obesity may thus not only prevent cardiovascular disease but also dementia, although it is difficult to prove the efficacy of these measures for dementía prevention

Topics: Clinical Research
Publisher: Les Laboratoires Servier
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. An 18-year follow-up of overweight and risk of Alzheimer disese.
  2. APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: The Three-City Study.
  3. Atherosclerosis and AD: Analysis of data from the US National Alzheimer’s Coordinating Center.
  4. Brain infarction and the clinical expression of Alzheimer disease.
  5. Can treatment with anti-inflammatory drugs protect against dementia? Arch Neurol.
  6. Cognitive function over time in Alzheimer's disease anti-inflammatory prevention trial (ADAPT).
  7. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.
  8. (1993). Geriatric depression: age of onset and dementia. Biol Psychiatry.
  9. Global prevalence of dementia: a Delphi consensus study.
  10. (2007). Late-life depression as a risk factor for dementia. Future Medicine.
  11. Mixed dementia – the most common cause of dementia.
  12. Neuropathology group of the medical research council cognitive function and ageing study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales.
  13. Neuropathology of older persons without cognitive impairment from two community-based studies.
  14. (1998). on behalf of the Syst-Eur Investigators. Prevention of dementia in randomized double-blind placebocontrolled systolic hypertension in Europe (Syst-Eur) trial.
  15. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease.
  16. Risk score for the prediction of dementia risk in. 20 years among middle aged people: a longitudinal, population-based study.
  17. (1998). Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort sdtudy: the Rotterdam Study.
  18. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.
  19. The complex nosological concept of vascular dementia.
  20. The prediction and prevention of Alzheimer's disease towards a research agenda.
  21. The prevention of the dementia epidemic.
  22. (2006). Vascular risk factors for incident Alzheimer disease and vascular dementia: The Cache County Study. Alzheimer Dis Assoc Disord.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.