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Malignant Fibrous Histiocytoma with In-Transit Metastasis

By Taku Fujimura, Masayuki Sugawara, Takahiro Haga, Yoshiyuki Kariya, Ryuhei Okuyama, Hachiro Tagami and Setsuya Aiba


Malignant fibrous histiocytoma (MFH) is the most common fibroblastic tumor, but its cutaneous metastasis, especially in-transit metastasis, is extremely rare. We describe the case of a 30-year-old Japanese man with a recurrent MFH on the scalp accompanied by in-transit metastasis, which had been treated as a benign skin tumor 8 years before. The main bulk of the recurrent tumor was located in the dermis, but the metastatic tumor was mainly located in the subcutis. Generally, atypical fibroxanthoma, also known as cutaneous MFH, is rarely metastasized and presents a benign clinical course. Since there is a great difference between the prognosis of MFH and atypical fibroxanthoma, precise diagnosis of the primary tumor is essential

Topics: Published: August 2011
Publisher: S. Karger AG
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Provided by: PubMed Central

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  1. Aiba S: Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases.
  2. (2001). Goldblum JR (eds): Enzinger and Weiss’s Soft tissue tumor: fourth edition.
  3. The CD99 signal enhances FAS-mediated apoptosis in the human leukemic cell lines,
  4. White CR Jr: Myxofibrosarcoma presenting in the skin: clinicopathological feature and differential diagnosis with cutaneous myxoid neoplasm.
  5. YC: Cutaneous metastatic malignant fibrous histiocytoma.
  6. Zhang P: CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker.