Article thumbnail

Antiplatelet antibody may cause delayed transfusion-related acute lung injury

By Yoshitaro Torii, Toshiki Shimizu, Takashi Yokoi, Hiroyuki Sugimoto, Yuichi Katashiba, Ryotaro Ozasa, Shinya Fujita, Yasushi Adachi, Masahiko Maki and Shosaku Nomura

Abstract

A 61-year-old woman with lung cancer developed delayed transfusion-related acute lung injury (TRALI) syndrome after transfusion of plasma- and leukoreduced red blood cells (RBCs) for gastrointestinal bleeding due to intestinal metastasis. Acute lung injury (ALI) recurred 31 days after the first ALI episode. Both ALI episodes occurred 48 hours after transfusion. Laboratory examinations revealed the presence of various antileukocyte antibodies including antiplatelet antibody in the recipient’s serum but not in the donors’ serum. The authors speculate that antiplatelet antibodies can have an inhibitory effect in the recipient, which can modulate the bona fide procedure of ALI and lead to a delay in the onset of ALI. This case illustrates the crucial role of a recipient’s platelets in the development of TRALI

Topics: Case Report
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:3177594
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). Acute lung injury following blood transfusion: expanding the definition. Crit Care Med.
  2. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury.
  3. (2004). Fatalities caused by TRALI. Transfus Med Rev.
  4. Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury. Clin Exp Immunol.
  5. (1991). New monoclonal anti-human Fc gamma receptor II antibodies induce platelet aggregation. Clin Exp Immunol.
  6. (1993). Platelet activation induced by an antiplatelet autoantibody against CD9 antigen and its inhibition by another autoantibody in immune thrombocytopenic purpura.
  7. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
  8. Roles of platelet-derived chemokines in various clinical settings. In:
  9. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury.