Article thumbnail

Statins Enhance Clonal Growth of Late Outgrowth Endothelial Progenitors and Increase Myocardial Capillary Density in the Chronically Ischemic Heart

By Wen Wang, Jennifer K. Lang, Gen Suzuki, John M. Canty and Thomas Cimato
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1997). 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium.
  2. (1998). A common precursor for hematopoietic and endothelial cells.
  3. (2008). Assessing identity, phenotype and fate of endothelial progenitor cells.
  4. (1998). Chronic heart failure in the United States.
  5. (2003). Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.
  6. (2000). Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events.
  7. (2006). Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands.
  8. (2007). Clonogenic endothelial progenitor cells are sensitive to oxidative stress.
  9. (2006). Cord blood stem and progenitor cells.
  10. (2010). Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction.
  11. (2002). Double-edged role of statins in angiogenesis signaling.
  12. (2007). Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors.
  13. (2006). High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine.
  14. (2001). HMGCoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/AKT pathway.
  15. (2007). Human CD34+AC133+VEGFR2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors.
  16. (2009). Identification of a coronary vascular progenitor cell in the human heart.
  17. (2004). Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.
  18. (2005). Intensive lipid lowering with Atorvastatin in patients with stable coronary disease.
  19. (2004). Intensive versus moderate lipid lowereing with statins after acute coronary syndromes.
  20. (2005). Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors contribute to distinct pharmacologic and pleiotrophic actions.
  21. (2010). Is endothelium the origin of endothelial progenitor cells? Arterioscler Thromb Vasc Biol 30: 1094–1103. Statins, EPCs, and Capillary Density PLoS
  22. (1997). Isolation of putative progenitor endothelial cells for angiogenesis.
  23. Kleinman HK (2010) In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract.
  24. (2009). Molecular basis of statin-associated myopathy.
  25. (2009). Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and c-kit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
  26. (2006). Primary prevention of cardiovascular diseases with statin therapy: A meta-analysis of randomized controlled trials.
  27. (2007). Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals.
  28. (1988). Role of laminin and basement membrane in the morphologic differentiation of human endothelial structures into capillary-like structures.
  29. (2003). Statin therapy and angiogenesis.
  30. (2002). Statins have biphasic effects on angiogenesis.
  31. (2004). The pro- and antiangiogenic effects of statins.