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Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells

By Sandrine Chamboredon, Delphine Ciais, Agnès Desroches-Castan, Pierre Savi, Françoise Bono, Jean-Jacques Feige and Nadia Cherradi


The study provides new evidence that the mRNA-destabilizing protein Tristetraprolin is a modulator of HIF-1α mRNA turnover and may contribute to the control of HIF-1α and HIF-1α target gene expression during the adaptive response of endothelial cells to hypoxia

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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