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Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

By Xingqian Zhang and Shu-Bing Qian

Abstract

Not only do molecular chaperones assist protein folding, they also facilitate the degradation of misfolded polypeptides. In coordinating with cochaperones CHIP and BAG3, Hsp70 can also target misfolded proteins to aggresomes, thereby protecting cells from proteotoxic stress

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3172255
Provided by: PubMed Central
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