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Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure

By Caroline Laplante and Laura A. Nilson


Upon loss of a binding partner in apposed tissue, the homophilic cell adhesion protein Echinoid adopts a planar polarized localization, which promotes the planar polarized localization of the planar cell polarity protein Bazooka/Par-3 and targets actomyosin cable assembly to the epidermal leading edge, thus establishing the migration direction of the developing epidermis

Topics: Research Articles
Publisher: The Rockefeller University Press
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Provided by: PubMed Central

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