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Cellular prion protein protects from inflammatory and neuropathic pain

By Vinicius M Gadotti and Gerald W Zamponi

Abstract

Cellular prion protein (PrPC) inhibits N-Methyl-D-Aspartate (NMDA) receptors. Since NMDA receptors play an important role in the transmission of pain signals in the dorsal horn of spinal cord, we thus wanted to determine if PrPC null mice show a reduced threshold for various pain behaviours

Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3170224
Provided by: PubMed Central

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