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Bayesian detection of non-sinusoidal periodic patterns in circadian expression data

By Darya Chudova, Alexander Ihler, Kevin K. Lin, Bogi Andersen and Padhraic Smyth

Abstract

Motivation: Cyclical biological processes such as cell division and circadian regulation produce coordinated periodic expression of thousands of genes. Identification of such genes and their expression patterns is a crucial step in discovering underlying regulatory mechanisms. Existing computational methods are biased toward discovering genes that follow sine-wave patterns

Topics: Original Papers
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3167694
Provided by: PubMed Central
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