Article thumbnail

The auxin signalling network translates dynamic input into robust patterning at the shoot apex

By Teva Vernoux, Géraldine Brunoud, Etienne Farcot, Valérie Morin, Hilde Van den Daele, Jonathan Legrand, Marina Oliva, Pradeep Das, Antoine Larrieu, Darren Wells, Yann Guédon, Lynne Armitage, Franck Picard, Soazig Guyomarc'h, Coralie Cellier, Geraint Parry, Rachil Koumproglou, John H Doonan, Mark Estelle, Christophe Godin, Stefan Kepinski, Malcolm Bennett, Lieven De Veylder and Jan Traas


We provide a comprehensive expression map of the different genes (TIR1/AFBs, ARFs and Aux/IAAs) involved in the signalling pathway regulating gene transcription in response to auxin in the shoot apical meristem (SAM).We demonstrate a relatively simple structure of this pathway using a high-throughput yeast two-hybrid approach to obtain the Aux/IAA-ARF full interactome.The topology of the signalling network was used to construct a model for auxin signalling and to predict a role for the spatial regulation of auxin signalling in patterning of the SAM.We used a new sensor to monitor the input in the auxin signalling pathway and to confirm the model prediction, thus demonstrating that auxin signalling is essential to create robust patterns at the SAM

Topics: Article
Publisher: Nature Publishing Group
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2001). 17: 2899–2910 Pfaffl MW
  2. (2008). Auxin influx carriers stabilize phyllotactic patterning. Genes Dev 22: 810–823 Barbier de Reuille
  3. (2011). Context, specificity, and selforganization in auxin response. Cold Spring Harb Perspect Biol 3: a001578 Desprez
  4. (2009). Integration of transport-based models for phyllotaxis and midvein formation.
  5. (2002). Miyawaki A
  6. (2004). Realtime RT–PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shootspecific genes.
  7. (2007). Specificity and similarity of functions of the Aux/IAA genes in auxin signaling of Arabidopsis revealed by promoter-exchange experiments among MSG2/IAA19, AXR2/IAA7, and SLR/IAA14.
  8. (2005). The Arabidopsis F-box protein TIR1 is an auxin receptor.