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RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

By Po-Ssu Huang, Yih-En Andrew Ban, Florian Richter, Ingemar Andre, Robert Vernon, William R. Schief and David Baker

Abstract

We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3166072
Provided by: PubMed Central

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