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Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences

By Melinda Butsch Kovacic, Jocelyn M. Biagini Myers, Ning Wang, Lisa J. Martin, Mark Lindsey, Mark B. Ericksen, Hua He, Tia L. Patterson, Tesfaye M. Baye, Dara Torgerson, Lindsey A. Roth, Jayanta Gupta, Umasundari Sivaprasad, Aaron M. Gibson, Anna M. Tsoras, Donglei Hu, Celeste Eng, Rocío Chapela, José R. Rodríguez-Santana, William Rodríguez-Cintrón, Pedro C. Avila, Kenneth Beckman, Max A. Seibold, Chris Gignoux, Salma M. Musaad, Weiguo Chen, Esteban González Burchard and Gurjit K. Khurana Hershey
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3166061
Provided by: PubMed Central

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  1. (2009). A
  2. (2007). A common variant on chromosome 9p21 affects the risk of myocardial infarction.
  3. (2003). A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood.
  4. (2009). A flexible and accurate genotype imputation method for the next generation of genome-wide association studies.
  5. (2007). A second generation human haplotype map of over 3.1 million SNPs.
  6. (2008). Accounting for ancestry: population substructure and genome-wide association studies.
  7. (2005). Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma.
  8. (1996). Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
  9. (2005). Asthma concepts in the new millennium: update in asthma pathophysiology.
  10. (2006). Asthma genetics 2006: the long and winding road to gene discovery.
  11. (1986). Definition and estimation of fixation indices.
  12. (2003). Efficient selective screening of haplotype tag SNPs.
  13. (2000). Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis.
  14. (2009). eQTL analysis in humans.
  15. (1984). Estimating F-statistics for the analysis of population structure.
  16. (2009). Finding the missing heritability of complex diseases.
  17. (2009). Franke A
  18. (2009). Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
  19. (2009). Genomewide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases.
  20. (2006). Heterogeneity of childhood asthma among Hispanic children: Puerto Rican children bear a disproportionate burden.
  21. (2003). Informativeness of genetic markers for inference of ancestry.
  22. (2007). Interleukin-4 promoter polymorphisms: a genetic prognostic factor for survival in metastatic renal cell carcinoma.
  23. (2002). Interrogating a highdensity SNP map for signatures of natural selection.
  24. (2011). KIF3A, a cilia structural gene on chromosome 5q31, and its polymorphisms show an association with aspirin hypersensitivity in asthma.
  25. (1995). KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.
  26. (2004). Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.
  27. (1998). Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture.
  28. (2003). Minimal haplotype tagging.
  29. (2008). Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies.
  30. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses.
  31. (2009). Point and interval estimation of partial attributable risks from case-control data using the R-package ‘pARccs’.
  32. (2003). Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data.
  33. (1991). Principal Component Analysis for Large Dispersion Matrices.
  34. (2006). Principal components analysis corrects for stratification in genome-wide association studies.
  35. (2005). Racial and ethnic differences in asthma diagnosis among children who wheeze.
  36. (2008). Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models.
  37. (2004). Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.
  38. (1991). Simplified mammalian DNA isolation procedure.
  39. (1987). Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors,
  40. (1951). The genetic structure of populations.
  41. (2002). The health of Latino children: urgent priorities, unanswered questions, and a research agenda.
  42. (2004). The immunogenetics of asthma and eczema: a new focus on the epithelium.
  43. (1998). The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee
  44. (2004). The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.
  45. Variability within and among Natural Populations:
  46. (2007). When cilia go bad: cilia defects and ciliopathies.